33545-40-3

Basic information

• Product Name: ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE
• Synonyms: ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE;ETHYL 5-FUR-2-YLISOXAZOLE-3-CARBOXYLATE;AKOS PAO-1403;ethyl 5-(furan-2-yl)-1,2-oxazole-3-carboxylate;Ethyl 5-(furan-2-yl)isoxazole-3-carboxylate;5-furan-2-yl-isoxazole-3-carboxylic acid ethyl ester;Ethyl 5-(furan-2-yl)
• CAS NO: 33545-40-3
• Molecular Formula: C10H9NO4
• Molecular Weight: 207.18
• Mol File: 33545-40-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 49 °C
• Boiling Point: 352.4°Cat760mmHg
• Flash Point: 166.9°C
• Appearance: /
• Density: 1.233g/cm³
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Refractive Index: 1.506
• CAS DataBase Reference: ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE(33545-40-3)
• EPA Substance Registry System: ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE(33545-40-3)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 33545-40-3(Hazardous Substances Data)

Usage

General Description

ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE is a chemical compound with the molecular formula C11H9NO4. It is a synthetic compound that is commonly used in the pharmaceutical and agrochemical industries. ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE is known for its isoxazole ring structure, which makes it a valuable building block for the synthesis of various pharmaceutical drugs and agrochemicals. It is also used as a ligand in coordination chemistry and in the synthesis of biologically active molecules. ETHYL 5-(2-FURYL)ISOXAZOLE-3-CARBOXYLATE is a versatile compound with a range of applications in the manufacturing of pharmaceuticals, agrochemicals, and other chemical products.

InChI:InChI=1/C10H9NO4/c1-2-13-10(12)7-6-9(15-11-7)8-4-3-5-14-8/h3-6H,2H2,1H3

Upstream product

• 36983-35-4 ethyl 4-(furan-2-yl)-2,4-dioxobutyrate 
• 33008-49-0 4-furan-2-yl-4-oxo-but-2-ynoic acid ethyl ester 
• 1192-62-7 1-(2-furyl)-1-ethanone 

Downstream Products

• 98434-06-1 5-(furan-2-yl)-1,2-oxazole-3-carboxylic acid 
• 90110-76-2 5-furan-2-yl-isoxazole-3-carboxylic acid hydrazide 
• 58589-69-8 3-(furan-2-yl)-1-phenyl-1H-pyrazol-5-amine 
• 852180-63-3 (5-furan-2-yl-isoxazol-3-yl)-methanol 

Relevant articles and documents

Synthesis of isoxazoles via cyclization of β-fluoro enones with sodium azide

A practical method for the synthesis of 3,5-disubstituted isoxazoles via cyclization of β-fluoro enones with sodium azide was disclosed. Density functional theory (DFT) calculation indicated that both (1) the azirine formation followed by intramolecular rearrangement and (2) direct enolate O-attack via 5-exo-trig cyclization of vinyl azide were possible for the isoxazole formation.

ATF6 INHIBITORS AND USES THEREOF

Compounds as inhibitors of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.

ISOXAZOLE DERIVATIVES AND USE THEREOF

Disclosed herein are isoxazole derivatives and uses thereof. Serving as agonists of Wnt, the isoxazole derivatives activate Wnt/beta-catenin signaling and thus can be used in the treatment and prevention of diseases related to the signal transduction. Also, pharmaceutically acceptable salts of the isoxazole derivatives are disclosed