335451-49-5

Basic information

• Product Name: 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine
• Synonyms: 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine
• CAS NO: 335451-49-5
• Molecular Weight: 458.697
• Mol File: 335451-49-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine(335451-49-5)
• EPA Substance Registry System: 1-(tert-Butyldimethylsilyl)-5-methoxy-N-(4-methylbenzenesulfonyl)tryptamine(335451-49-5)

Safety Data

• Hazardous Substances Data: 335451-49-5(Hazardous Substances Data)

Upstream product

• 250672-50-5 1-(tert-butyldimethylsilyl)-3-bromo-5-methoxy-1H-indole 
• 1006-94-6 5-methoxylindole 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 162710-95-4 1-(tert-Butyldimethylsilyl)-5-methoxyindole 

Downstream Products

• 73-31-4 5-methoxy-N-acetyl-tryptamine 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 102016-76-2 N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Preparation and reactions of 4-, 5-, and 6-methoxy substituted 3-lithioindoles and 3-indolylzinc derivatives

The preparation of 4-, 5-, and 6-methoxy substituted 3-lithio-1-(trialkylsilyl)indoles 4b-d by metalation of the corresponding 3-bromoindoles, and their reactions with iodomethane, DMF, ethylene oxide and aziridines are reported. Transmetalation of 3-lithioindoles 4b-d with ZnCl2 afforded 3-indolylzinc chlorides 11b-d, which underwent Pd(0)-catalyzed cross-coupling reactions with 2-halopyridines to give 4-, 5-, and 6-methoxy substituted 3-(2-pyridyl)indoles.