33553-82-1

Basic information

• Product Name: Benzenemethanol, a-(3-chloropropyl)-
• CAS NO: 33553-82-1
• Molecular Formula: C10H13ClO
• Molecular Weight: 184.666
• Mol File: 33553-82-1.mol
• Article Data: 17

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, a-(3-chloropropyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-(3-chloropropyl)-(33553-82-1)
• EPA Substance Registry System: Benzenemethanol, a-(3-chloropropyl)-(33553-82-1)

Safety Data

• Hazardous Substances Data: 33553-82-1(Hazardous Substances Data)

Upstream product

• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 71-43-2 benzene 
• 935-64-8 1-phenyl-1-cyclobutanol 
• 501-53-1 benzyl chloroformate 
• 22815-63-0 N-^t-butyl benzylcarbamate 
• 126404-88-4 tert-Butyl-carbamic acid 4-chloro-1-phenyl-butyl ester 

Downstream Products

• 1373440-07-3 (1-bromo-4-chlorobutyl)benzene 
• 939-52-6 4-chloro-1-phenylbutan-1-one 
• 1469994-82-8 2-deuterio-2-phenyltetrahydrofuran 
• 16133-83-8 tetrahydro-2-phenylfuran 
• 53380-21-5 γ-ethyl-γ-phenyl-butyrolactone 
• 60507-03-1 acetophenone-d1 
• 1469994-92-0 diphenyl(2-phenyltetrahydrofuran-2-yl)phosphine 
• 1469994-91-9 2-phenyltetrahydrofuran-2-carbaldehyde 
• 1469994-88-4 2-(2-phenyltetrahydrofuran-2-yl)propan-2-ol 
• 1469994-85-1 2-phenyl-2-(phenylthio)tetrahydrofuran 
• 1469994-84-0 2-phenyl-2-(tributylstannyl)tetrahydrofuran 
• 1469994-83-9 trimethyl(2-phenyltetrahydrofuran-2-yl)silane 
• 87372-61-0 2-phenyl-2-allyltetrahydrofuran 
• 190206-05-4 1-(4-mercapto-1-phenylbutyl)-1-cyclopentanol 

Relevant articles and documents

Copper-Catalyzed Enantioconvergent Cross-Coupling of Racemic Alkyl Bromides with Azole C(sp2)?H Bonds

The development of enantioconvergent cross-coupling of racemic alkyl halides directly with heteroarene C(sp2)?H bonds has been impeded by the use of a base at elevated temperature that leads to racemization. We herein report a copper(I)/cinchona-alkaloid-derived N,N,P-ligand catalytic system that enables oxidative addition with racemic alkyl bromides under mild conditions. Thus, coupling with azole C(sp2)?H bonds has been achieved in high enantioselectivity, affording a number of potentially useful α-chiral alkylated azoles, such as 1,3,4-oxadiazoles, oxazoles, and benzo[d]oxazoles as well as 1,3,4-triazoles, for drug discovery. Mechanistic experiments indicated facile deprotonation of an azole C(sp2)?H bond and the involvement of alkyl radical species under the reaction conditions.

Copper-Catalyzed N?F Bond Activation for Uniform Intramolecular C?H Amination Yielding Pyrrolidines and Piperidines

The dual function of the N?F bond as an effective oxidant and subsequent nitrogen source in intramolecular aliphatic C?H functionalization reactions is explored. Copper catalysis is demonstrated to exercise full regio- and chemoselectivity control, which

Regioselective Synthesis of Carbonyl-Containing Alkyl Chlorides via Silver-Catalyzed Ring-Opening Chlorination of Cycloalkanols

A novel and regioselective approach to carbonyl-containing alkyl chlorides via silver-catalyzed ring-opening chlorination of cycloalkanols is reported. Concurrent C(sp3)-C(sp3) bond cleavage and C(sp3)-Cl bond formation efficiently occur with good yields under mild conditions, and the chlorinated products are readily transformed into other useful synthetic intermediates and drugs. The reaction features complete regioselectivity, high efficiency, and excellent practicality. (Chemical Equation Presented).