33564-31-7

Basic information

• Product Name: Diflorasone diacetate
• Synonyms: (6-alpha,11-beta,16-beta)-thyl;pregna-1,4-diene-3,20-dione,17,21-bis(acetyloxy)-6,9-difluoro-11-hydroxy-16-me;FLORONE;DIFLORASONE DIACETATE;6a,9-difluoro-11b,17,21-trihydroxy-16b-methylpregna-1,4-diene-3,20-dione 17,21-diacetate;6ALPHA,9-DIFLUORO-11BETA,17,21-TRIHYDROXY-16BETA-METHYLPREGNA-1,4-DIENE-3,20-DIONE 17,21-DIACETATE;6 ALPHA,9-DIFLUORO-11 BETA,17,21-TRIHYDROXY-16 BETA-METHYLPREGNA-1,4-DIENE-3,20-DIONE-17,21-DIACETE;6α,9-difluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate
• CAS NO: 33564-31-7
• Molecular Formula: C₂₆H₃₂F₂O₇
• Molecular Weight: 494.52
• EINECS: 251-575-1
• Product Categories: Steroids;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 33564-31-7.mol
• Article Data: 7

Chemical Properties

• Melting Point: 221-223° (dec)
• Boiling Point: 235°C (rough estimate)
• Flash Point: 307.6 °C
• Appearance: /
• Density: 1.2001 (estimate)
• Refractive Index: 1.546
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 12.63±0.70(Predicted)
• Water Solubility: 6.5mg/L(22 oC)
• CAS DataBase Reference: Diflorasone diacetate(CAS DataBase Reference)
• NIST Chemistry Reference: Diflorasone diacetate(33564-31-7)
• EPA Substance Registry System: Diflorasone diacetate(33564-31-7)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22-40
• Safety Statements: 22-36
• WGK Germany: 3
• RTECS: TU3722000
• Hazardous Substances Data: 33564-31-7(Hazardous Substances Data)

Usage

Description

Diflorasone diacetate, also known as the 17,21-diacetate derivative of diflorasone, is a white solid with anti-inflammatory and antipruritic properties. It is a pharmaceutical compound that has been developed for the treatment of various skin disorders.

Uses

Used in Pharmaceutical Industry:
Diflorasone diacetate is used as a topical medication for its anti-inflammatory and antipruritic properties. It is particularly effective in the treatment of various skin disorders, such as eczema, dermatitis, and other inflammatory skin conditions. Diflorasone diacetate works by reducing the inflammation and itching associated with these conditions, providing relief and promoting healing of the affected skin areas.

Therapeutic Function

Antiinflammatory

InChI:InChI=1/C26H32F2O7/c1-13-8-17-18-10-20(27)19-9-16(32)6-7-23(19,4)25(18,28)22(34-14(2)30)11-24(17,5)26(13,21(33)12-29)35-15(3)31/h6-7,9,13,17-18,20,22,29H,8,10-12H2,1-5H3/t13-,17-,18-,20-,22-,23-,24-,25-,26-/m0/s1

Upstream product

• 50630-17-6 6α-fluoro-9β,11β-epoxy-17α,21-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-diacetate 
• 50630-15-4 6α,9α-difluoro-11β,17α,21-trihydroxy-16β-methylpregn-4-ene-3,20-dione 17,21-diacetate 
• 84-58-2 2,3-dicyano-5,6-dichloro-p-benzoquinone 
• 50630-13-2 6α-fluoro-16β-methyl-17α,21-diacetoxypregna-4,9(11)-diene-3,20-dione 
• 50763-89-8 6α-fluoro-17α,21-dihydroxy-16β-methylpregna-4,9(11)-diene-3,20-dione 21-acetate 

Relevant articles and documents

Method for the preparation of 6alpha-fluoro corticosteroids

A method for producing a 6α-fluorinated corticosteroid or derivative thereof by reacting a 17-hydroxy-21-ester epoxide of Formula II with a stereoselective fluorinating agent to stereoselectively form a 21-ester-17-hydroxy 6α-fluorinated compound of Formula VII R1 can be OC(O)—Rd; R4 can be C(O)—Rd; R3 can be H or Rd. Each Rd may be the same or different and is independently selected from (C1-4)alkyl, aryl and heteroaryl. The dashed line can be a single or a double bond. R4 may be, for example, acetyl; R3 may be, for example, alpha or beta methyl; R4 may be, for example, acetate or propionate. The stereoselective fluorinating agent used in the reaction may be, for example, a fluoropyridinium or fluoroquinuclidium compound, for example, Selectfluor?.

Process and intermediates for the preparation of 17 alphahydroxyprogesterones and corticoids from an enol steroid

This invention discloses an improved process for the production of corticoids from 17α-hydroxy steroids utilizing peroxymonosulfate.

3-Acetoxy-9β-11β-epoxy-dienes and the preparation of the corresponding 6α-halogen-4-ene-3-ones

The invention relates to 3-acetoxy-9β,11β,-epoxy-pregna-1,3,5-trienes and the corresponding 3,5-dienes having the general formula 1, in which on the 1,2-position a double bond may be present and in which R3 is a hydrogen or halogen atom or a hyroxy-, acyloxy-, aroyloxy or sulphonyloxygroup; R1 and/or R2 are a hydrogen atom or a hydroxy-, aroyloxy-, acyloxy- or alkylgroup containing 1-6 carbon atoms, or in which R1 and R2 form together a 16,17-isopropylidene-dioxy group, a process for the preparation of this compounds by reacting the corresponding Δ1,4 -3-keto-pregnadienes or Δ4 -3-keto-pregnenes with isopropenylacetate and a process for their direct conversion into the corresponding 6α-halogen-substituted-pregna-1,4-diene-3-ones and pregn-4-ene-3-ones with the general formula 2 by reacting them with a positive-halogen producing agent.