3357-54-8

Basic information

• Product Name: ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE
• Synonyms: ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE;4-Oxazolecarboxylicacid, 5-aMino-2-Methyl-, ethyl ester;5-Amino-2-methyl-oxazole-4-carboxylic acid ethyl ester
• CAS NO: 3357-54-8
• Molecular Formula: C₇H₁₀N₂O₃
• Molecular Weight: 170.17
• EINECS: 200-589-5
• Mol File: 3357-54-8.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE(3357-54-8)
• EPA Substance Registry System: ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE(3357-54-8)

Safety Data

• Hazardous Substances Data: 3357-54-8(Hazardous Substances Data)

Usage

General Description

ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE is a chemical compound with the molecular formula C7H9N3O3. It is a white powder that is commonly used in the synthesis of various pharmaceuticals and agrochemicals. ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE is known for its ability to act as a precursor in the preparation of non-nucleoside reverse transcriptase inhibitors, which are important in the treatment of HIV. Additionally, it has been utilized in the production of fungicides and herbicides due to its antimicrobial and pesticidal properties. ETHYL 5-AMINO-2-METHYLOXAZOLE-4-CARBOXYLATE is a versatile and important chemical in the field of pharmaceutical and agricultural industries.

Upstream product

• 819877-81-1 C₆H₁₀ClNO₃ 
• 5804-85-3 diethylaluminium cyanide 
• 105-56-6 ethyl 2-cyanoacetate 
• 90877-70-6 ethyl 2-acetamido-2-cyanoacetate 
• 3849-21-6 ethyl cyanoglyoxylate-2-oxime 
• 32683-02-6 ethyl-2-aminocyano acetate 

Downstream Products

• 99419-09-7 5-amino-2-methyl-oxazole-4-carboxylic acid hydrazide 
• 1262860-67-2 5-tert-Butoxycarbonylamino-2-methyl-oxazole-4-carboxylic acid 

Relevant articles and documents

New efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones via an oxazolyliminophosphorane

A new efficient synthesis of 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones by consecutive aza-Wittig reaction was developed. The sequential three-component reaction of oxazolyliminophosphorane 4, isocyanates and amines produced 2,5,6-trisubstituted oxazolo[5,4-d]pyrimidi-7(6H)-ones 7 in good overall yields in the presence of catalytic amount of EtONa.

Dihydrooxazolo[5,4-d]pyrrolo[1,2-a]pyrimidine-9(5H)-one derivative and application thereof

The invention relates to a dihydrooxazolo[5,4-d]pyrrolo[1,2-a]pyrimidine-9(5H)-one derivative and application. The preparation method comprises the following steps: by taking ethyl cyanoacetate as an initial raw material, generating a hydroxylamine compound (A) under the action of sodium nitrite and phosphoric acid, reducing with sodium hydrosulfite to obtain ethyl 2-aminocyanoacetate (B), reacting with different substituted acyl chlorides respectively under an alkali condition, generating different substituted oxazole compounds D1-D48 of 5-amino-4-formate under the action of trifluoroacetic acid, and reacting with pyrrolidone under the action of phosphorus oxychloride to obtain a dihydrooxazolo[5,4-d]pyrrolo[1,2-a]pyrimidine-9(5H)-one compound E1-E48. According to the invention, the inhibition activity of 48g of the compounds on Hela cervical cancer cells, MCF7 breast cancer cells and A549 lung cancer cells is investigated, and results show that the compounds E5, E10, E13, E16, E18, E19, E24, E42 and E43 have inhibition activity on Hela cervical cancer cells, the compounds E22, E24, E47 and E48 have inhibitory activity on MCF7 breast cancer cells, and the compounds E18 and E20 have inhibitory activity on A549 lung cancer cells.

Tetrahydrooxazolopyridino-oxaazaone derivative and application of tetrahydrooxazolopyridino-oxaazaone derivative

The invention relates to a tetrahydrooxazolopyridino-oxaazaone derivative and application thereof. Specifically, the derivative tetrahydrooxazolo[5',4' : 4,5]pyridino[1, 2-a]oxaaza-11(5H)-one derivatives E1-E48. In anti-tumor activity screening, the positive control of DOX is used; the inhibition effect of the 48 tetrahydrooxazolo[5',4':4,5]pyridino[1, 2-a]oxaaza-11(5H)-one derivatives E1-E48 on Hela human cervical cancer cells, MCF-7 breast cancer cells and A549 lung cancer cells is observed, and the results show that compared with the positive control, the compounds E5, E8, E9, E20, E26, E28, E32, E34, E38, E41, E42, E44, E45, E46, E47 and E48 have the inhibition activity on the Hela cervical cancer cells, the compounds E26, E38, E42, E45, E46 and E47 have inhibitory activity on MCF-7 breast cancer cells; and the compounds E8, E9, E26 and E47 have inhibitory activity on A549 lung cancer cells.