33598-78-6

Basic information

• Product Name: ETHANOLAMINE-15N
• Synonyms: ETHANOLAMINE-15N;2-Aminoethanol-15N
• CAS NO: 33598-78-6
• Molecular Formula: C2H7NO
• Molecular Weight: 62.09
• Mol File: 33598-78-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 11 °C(lit.)
• Boiling Point: 170 °C(lit.)
• Flash Point: 93°C
• Appearance: /
• Density: 1.028 g/mL at 25 °C
• CAS DataBase Reference: ETHANOLAMINE-15N(CAS DataBase Reference)
• NIST Chemistry Reference: ETHANOLAMINE-15N(33598-78-6)
• EPA Substance Registry System: ETHANOLAMINE-15N(33598-78-6)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-34
• Safety Statements: 26-36/37/39-45
• RIDADR: UN 2491 8 / PGIII
• WGK Germany: 1
• Hazardous Substances Data: 33598-78-6(Hazardous Substances Data)

Usage

General Description

ETHANOLAMINE-15N is a stable isotope of ethanolamine, a viscous, colorless liquid commonly used in the production of detergents, cosmetics, and pharmaceuticals. It is composed of a nitrogen atom that has been replaced with the stable isotope nitrogen-15, making it a useful tool for studies involving metabolic processes and chemical reactions. ETHANOLAMINE-15N is highly reactive and can be toxic in high concentrations, so proper handling precautions should be taken when working with it. Additionally, ETHANOLAMINE-15N can be used as a tracer in biological and chemical research to track the movement and transformation of nitrogen within different systems.

Upstream product

• 117500-42-2 glycine-15N ethyl ester 
• 58265-66-0 <15N>-2-Hydroxyethylphthalid 
• 72634-71-0 [¹⁵N]-glycine methyl ester hydrochloride 
• 7299-33-4 glycine-15N 

Relevant articles and documents

Synthesis of 15N labelled isophosphoramide mustard

The ifosfamide metabolite isophosphoramide mustard (IPM) was synthesized with isotopic enrichment at each nitrogen site. Glycine-15N was converted to 2-chloroethylamine-15N hydrochloride (4 steps, 21% net yield) which was then reacte

COMPOUND, DIAGNOSTIC AGENT, NUCLEAR MAGNETIC RESONANCE ANALYSIS METHOD, NUCLEAR MAGNETIC RESONANCE IMAGING METHOD, MASS SPECTROMETRY METHOD AND MASS SPECTROMETRY IMAGING METHOD

To produce a labeled compound for a selected biological substance not using a radioisotope atom which has a risk of exposure to radioactivity and limitation on handling time but using a stable isotope atom; and that the labeled compound can be measured with good sensitivity separably from naturally occurring compounds of the selected biological substance which are substituted with the stable isotope atom. Choline as a biological substance is labeled by substituting the nitrogen atom of the quaternary ammonium group and all the carbon atoms of the methyl group attached to the nitrogen atom with respective isotopes 15N and 13C and used as a diagnostic agent.

Hydrolysis of phosphotriesters: Determination of transition states in parallel reactions by heavy-atom isotope effects

The remote label method was used to measure primary and secondary 18O isotope effects in the alkaline hydrolysis of O,O-diethylphosphorylcholine iodide (DEPC) and the primary 18O effect in the alkaline hydrolysis of O,O-diethyl-m-nitrobenzyl phosphate (DEmNBP). Both the leaving group of interest (choline or m-nitrobenzyl alcohol) and ethanol can be ejected during hydrolysis due to the similarity of their pK values. The heavy-atom isotope effects were measured by isotope ratio mass spectrometry. Parallel reaction and incomplete labeling corrections were made for both systems. DEPC has a primary 18O isotope effect of 1.041 ± 0.003 and a secondary 18O isotope effect of 1.033 ± 0.002. The primary 18O isotope effect for DEmNBP was 1.052 ± 0.003. These large effects suggest a highly associative transition state in which the nucleophile approaches very close to the phosphorus atom to eject the leaving group. The large values are also indicative of a large compression, or general movement, on the reaction coordinate.