3360-81-4

Basic information

• Product Name: N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide
• Synonyms: N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide
• CAS NO: 3360-81-4
• Molecular Formula: C₁₄H₁₄N₂O₅S
• Molecular Weight: 322.33636
• Mol File: 3360-81-4.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 498.4°Cat760mmHg
• Flash Point: 255.3°C
• Appearance: /
• Density: 1.397g/cm³
• Vapor Pressure: 4.53E-10mmHg at 25°C
• Refractive Index: 1.619
• CAS DataBase Reference: N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide(3360-81-4)
• EPA Substance Registry System: N-(4-Methoxy-2-nitrophenyl)-4-methylbenzenesulfonamide(3360-81-4)

Safety Data

• Hazardous Substances Data: 3360-81-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C14H14N2O5S/c1-10-3-6-12(7-4-10)22(19,20)15-13-8-5-11(21-2)9-14(13)16(17)18/h3-9,15H,1-2H3

Upstream product

• 1150-26-1 N-(4-Methoxy-phenyl)-4-methyl-benzenesulfonamide 
• 98-59-9 p-toluenesulfonyl chloride 
• 96-96-8 4-methoxy-2-nitroaniline 
• 7697-37-2 nitric acid 
• 104-94-9 4-methoxy-aniline 

Downstream Products

• 674815-15-7 toluene-4-sulfonic acid-[N-(3-diethylamino-propyl)-4-methoxy-2-nitro-anilide] 
• 304913-71-1 toluene-4-sulfonic acid-(4-methoxy-2-nitro-N-propyl-anilide) 
• 96-96-8 4-methoxy-2-nitroaniline 
• 854638-14-5 toluene-4-sulfonic acid-[N-(2-diethylamino-ethyl)-4-methoxy-2-nitro-anilide] 
• 3360-80-3 toluene-4-sulfonic acid-(4-methoxy-N-methyl-2-nitro-anilide) 
• 13017-31-7 N-(2-Morpholino-ethyl)-N-(p-toluolsulfonyl)-2-nitro-4-methoxy-anilin 
• 7288-56-4 N-(4-chlorobenzyl)-N-<(4-methylphenyl)sulfonyl>-2-nitro-4-methoxyaniline 
• 16058-88-1 N-(2-Bromoethyl)-N-tosyl-4-methoxy-2-nitraniline 
• 86439-27-2 N-(2-hydroxyethyl)-4'-methoxy-2'-nitrotosylanilide 
• 7187-24-8 N¹-(4-chlorobenzyl)-4-methoxybenzene-1,2-diamine 
• 136122-75-3 4-[1-(4-Chloro-benzyl)-5-methoxy-1H-benzoimidazol-2-yl]-3,3-dimethyl-butyric acid ethyl ester 
• 86439-32-9 9-methoxy-2-methyl-6-tosyl-5,6-dihydro-4H-3,1,6-benzoxadiazocine 
• 86439-30-7 ethyl N-<2--4-methoxyphenyl>acetamidate 
• 86439-31-8 1-acetyl-2-ethoxy-9-methoxy-2-methyl-6-tosyl-1,4,5,6-tetrahydro-2H-3,1,6-benzoxadiazocine 

Relevant articles and documents

Triple Mode of Alkylation with Ethyl Bromodifluoroacetate: N, or O-Difluoromethylation, N-Ethylation and S-(ethoxycarbonyl)difluoromethylation

In this report, we have explored a triple mode of chemical reactivity of ethyl bromodifluoroacetate. Typically, bromodifluoroacetic acid has been used as a difluorocarbene precursor for difluoromethylation of soft nucleophiles. Here we have disclosed nucleophilicity and base dependent divergent chemical reactivity of ethyl bromodifluoroacetate. It furnishes lithium hydroxide and cesium carbonate promoted difluoromethylation of tosyl-protected aniline and electron-deficient phenols respectively. Interestingly, switching the base from lithium hydroxide to 4-N,N-dimethylamino pyridine (DMAP) tosyl-protected anilines afforded the corresponding N-ethylation product. Whereas, highly nucleophilic thiophenols furnished the corresponding S-carboethoxydifluoromethylation product via a rapid SN2 attack to the bromine atom prior to the ester hydrolysis. This mechanistic divergence was established through several control experiments. It was revealed that difluoromethylation reaction proceeds through a tandem in situ ester hydrolysis/decarboxylative-debrominative difluorocarbene formation and subsequent trapping by the soft nucleophile-NHTs or electron-deficient phenolic ?OH groups. In the presence of DMAP the hydrolysis of the ester is perturbed instead a nucleophilic attack at the ethyl moiety provides the N-ethylation product. Hence, besides the development of a practical base-promoted N-difluoromethylation of amines and electron-deficient phenols, divergent reactivity pattern of inexpensive and user-friendly ethyl bromodifluoroacetate has been explored. (Figure presented.).

Direct oxidative nitration of aromatic sulfonamides under mild conditions

A direct nitration of aromatic sulfonamides using sodium nitrite as the nitrating agent has been developed. The reaction shows typically mono-substitution selectivity and can be enlarged to the gram scale with good yield.

Synthesis and Structure - Activity Relationships of Novel Benzimidazole and Imidazopyridine Acid Derivatives as Thromboxane A2 Receptor Antagonists

A series of 1-benzylbenzimidazole and 3-benzylimidazopyridine substituted in the 2-position by an alkanoic or mercaptoalkanoic acid chain was synthesized for evaluation as potential thromboxane A2/prostaglandin H2 (TXA2/PGH2) receptor antagonists.T