3361-72-6

Basic information

• Product Name: 1-Propanone, 1-(2,6-dihydroxyphenyl)-
• CAS NO: 3361-72-6
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Mol File: 3361-72-6.mol
• Article Data: 10

Chemical Properties

• CAS DataBase Reference: 1-Propanone, 1-(2,6-dihydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Propanone, 1-(2,6-dihydroxyphenyl)-(3361-72-6)
• EPA Substance Registry System: 1-Propanone, 1-(2,6-dihydroxyphenyl)-(3361-72-6)

Safety Data

• Hazardous Substances Data: 3361-72-6(Hazardous Substances Data)

Usage

Molecular weight

224.26 g/mol

Appearance

White to off-white crystalline powder

Solubility

Slightly soluble in water, soluble in ethanol and methanol

Occurrence

Naturally occurring compound found in various plant species such as bearberry, blueberry, cranberry, and pear

Uses

Commonly used in cosmetic and skincare products for its skin-lightening and antioxidant properties

Mechanism of action

Inhibits the production of melanin in the skin, reducing the appearance of dark spots, hyperpigmentation, and uneven skin tone

Popularity in products

Included in treatments for acne, eczema, and age spots

Safety

Considered a safe and effective alternative to hydroquinone, a controversial skin-lightening chemical banned in certain countries due to potential harmful effects.

Upstream product

• 103204-97-3 2,4-dihydroxy-3-propionyl-benzoic acid 
• 108-46-3 recorcinol 
• 3361-13-5 4-methyl-2-oxo-2H-chromen-7-yl propionate 
• 90-33-5 7-hydroxy-4-methyl-chromen-2-one 
• 104775-30-6 2-propionyl-3-hydroxy-2-cyclohexen-1-one 
• 123-91-1 1,4-dioxane 
• 2150-47-2 methyl 2,4-dihydroxybenzoate 
• 57234-29-4 1,3-bis(methoxymethyl)resorcinol 
• 101408-95-1 2-chloro-2-propionyl-1,3-cyclohexanedione 
• 62847-90-9 2-propionylcyclohexene-1,3-dione 
• 3361-71-5 7-hydroxy-8-propionyl-4-methylcoumarin 

Downstream Products

• 1365681-88-4 diethyl 2-(3-(3-(3-chloropropoxy)-2-propionylphenoxy)propyl)malonate 
• 1365681-95-3 1-(2-(3-(butylamino)propoxy)-6-hydroxyphenyl)propan-1-one 
• 1365682-02-5 1-(2-hydroxy-6-(3-(p-tolylamino)propoxy)phenyl)propan-1-one 
• 1365682-08-1 1-(2-hydroxy-6-(3-(4-methoxyphenylamino)propoxy)phenyl)propan-1-one 
• 1365682-14-9 1-(2-(3-(butyl(methyl)amino)propoxy)-6-hydroxyphenyl)propan-1-one 
• 1365682-21-8 1-(2-hydroxy-6-(3-(pyrrolidin-1-yl)propoxy)phenyl)propan-1-one 
• 1365682-28-5 1-(2-hydroxy-6-(3-(piperidin-1-yl)propoxy)phenyl)propan-1-one 
• 1365682-36-5 diethyl 2-(3-(2-propionyl-3-(3-(p-tolylamino)propoxy)phenoxy)propyl)malonate 
• 1365682-42-3 diethyl 2-(3-(3-(2-(dimethylamino)ethoxy)-2-propionylphenoxy)propyl)malonate 
• 1365681-46-4 1-(2-(2-(dimethylamino)ethoxy)-6-hydroxyphenyl)propan-1-one 
• 1365681-53-3 1-(2-(2-(diethylamino)ethoxy)-6-hydroxyphenyl)propan-1-one 
• 1365682-48-9 diethyl 2-(3-(3-(2-(diethylamino)ethoxy)-2-propionylphenoxy)propyl)malonate 
• 1365681-67-9 1-(2-hydroxy-6-(2-(piperidin-1-yl)ethoxy)phenyl)propan-1-one 
• 1365682-58-1 diethyl 2-(3-(3-(2-(piperidin-1-yl)ethoxy)-2-propionylphenoxy)propyl)malonate 

Relevant articles and documents

HYDANTOIN DERIVATIVES USEFUL AS KV3 INHIBITORS

The invention provides compounds of formula (I): Said compounds being inhibitors of Kv3 channels and of use in the prophylaxis or treatment of related disorders.

Synthesis of propiophenone derivatives as new class of antidiabetic agents reducing body weight in db/db mice

A series of propiophenone derivatives (6-23) have been synthesized and evaluated for their in vivo antihyperglycemic activities in sucrose loaded model (SLM), sucrose challenged streptozotocin (STZ-S) induced diabetic rat model and C57BL/KsJ db/db diabetic mice model. Compound 15 and 16 were emerged as potent antihyperglycemics and lipid lowering agents. These compounds (15, 16) further validate the potency by reducing body weight and food intake in db/db mice model. Possible mechanism of action for the propiophenone derivatives was established by the evaluation in various in vitro models. Interestingly some of the compounds were efficiently inhibiting PTP-1B.

Design and synthesis of novel benzofurans as a new class of antifungal agents targeting fungal N-myristoyltransferase. Part 1

Potent and selective Candida albicans N-myristoyltransferase (CaNmt) inhibitors have been identified through optimization of a lead compound 1 discovered by random screening. The inhibitor design is based on the crystal structure of the CaNmt complex with compound (S)-3 and structure-activity relationships (SARs) have been clarified. Modification of the C-4 side chain of 1 has led to the discovery of a potent and selective CaNmt inhibitor 11 (RO-09-4609), which exhibits antifungal activity against C. albicans in vitro.