336105-24-9

Basic information

• Product Name: (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide
• Synonyms: (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide
• CAS NO: 336105-24-9
• Molecular Weight: 288.208
• Mol File: 336105-24-9.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide(336105-24-9)
• EPA Substance Registry System: (R)-(-)-N-[(1E)-(4-bromophenyl)methylene]-2-methyl-2-propanesulfinamide(336105-24-9)

Safety Data

• Hazardous Substances Data: 336105-24-9(Hazardous Substances Data)

Upstream product

• 1122-91-4 4-bromo-benzaldehyde 
• 196929-78-9 (R)-2-methylpropane-2-sulfinamide 

Downstream Products

• 451503-19-8 (R)-N-((R)-(4-bromophenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide 
• 451503-18-7 (R)-N-((S)-(4-bromophenyl)(phenyl)methyl)-2-methylpropane-2-sulfinamide 
• 220441-82-7 (S)-(4-bromophenyl)(phenyl)methanamine 
• 1428526-95-7 (R)-N-((R)-(4-bromophenyl)(4-fluorophenyl)methyl)-2-methylpropane-2-sulfinamide 
• 1428527-51-8 4-((R)-(2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxamido)(4-fluorophenyl)methyl)phenyl(methyl)phosphinic acid 
• 1428527-50-7 ethyl 4-((R)-(2-(4-fluoro-1H-pyrazol-1-yl)-4-hydroxypyrimidine-5-carboxamido)(4-fluorophenyl)methyl)phenyl(methyl)phosphinate 
• 1428527-23-4 4-((R)-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl) methyl)phenyl(methyl)phosphinic acid 
• 1428527-22-3 ethyl 4-((R)-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl) methyl)phenyl(methyl)phosphinate 
• 1428527-20-1 ethyl 4-((R)-((R)-1,1-dimethylethylsulfinamido)(phenyl)methyl)phenyl(methyl)phosphinate 
• 1428527-19-8 4-((S)-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl)methyl)phenyl(methyl)phosphinic acid 
• 1428527-18-7 ethyl 4-((S)-(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)(phenyl) methyl)phenyl(methyl)phosphinate 
• 1428527-16-5 ethyl 4-((S)-((R)-1,1-dimethylethylsulfinamido)(phenyl)methyl)phenyl(methyl)phosphinate 
• 1428526-99-1 4-((R)-(4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinic acid 
• 1428526-98-0 ethyl 4-((R)-(4-fluorophenyl)(4-hydroxy-2-(1H-pyrazol-1-yl)pyrimidine-5-carboxamido)methyl)phenyl(methyl)phosphinate 

Relevant articles and documents

Stereoselective Coupling of N-tert-Butanesulfinyl Aldimines and β-Keto Acids: Access to β-Amino Ketones

The reaction of chiral N-tert-butanesulfinyl aldimines with β-keto acids under basic conditions at room temperature proceeds with high levels of diastereocontrol, leading to β-amino ketones in high yields. Based on DFT calculations, an eight-membered cyclic transition state involving coordination of the lithium atom to the oxygens of carboxylate and sulfinyl units was proposed, being in agreement with the observed experimental diastereomeric ratios. The synthesis of the piperidine alkaloid (-)-pelletierine was successfully undertaken in order to demonstrate the utility of this methodology.

SUBSTITUTED PYRIMIDINES

The present invention relates to substituted pyrimidines useful as HIF prolyl hydroxylase inhibitors to treat anemia and like conditions.