336129-03-4Relevant articles and documents
Rapid construction of C4-substituted phenanthridinones through palladium-catalyzed domino N-arylation/aryl-aryl coupling process
Liu, Chao,Song, Liangliang,Van Meervelt, Luc,Van der Eycken, Erik V.
, (2021/08/05)
An excellent chemo- and regioselective palladium-catalyzed cascade intermolecular N-arylation/aryl-aryl coupling process has been developed. Employing Pd(TFA)2, PCy3?HBF4, K2CO3 and 1,4-dioxane in an oil bath at 100°C for 12 h, diverse C4-substituted phenanthridinones are synthesized from o-bromobenzamides in 42-92% yield. Broad substrate scope and excellent functional group tolerance are observed. The synthetic utility of this method is illustrated by the further derivatization to prepare multiple-substituted phenanthridinones in 30-75% yield.
Efficient synthesis of phenanthridinone derivatives via a palladium-catalyzed coupling process
Furuta, Takumi,Kitamura, Yuki,Hashimoto, Ayano,Fujii, Satoshi,Tanaka, Kiyoshi,Kan, Toshiyuki
, p. 183 - 186 (2007/10/03)
(Chemical Equation Presented) A palladium-mediated domino reaction was developed to conveniently synthesize phenanthridinone derivatives. Phosphine ligand 1 strongly promotes the domino process, which includes aryl-aryl coupling and C-N bond formations concomitant with a deamidation reaction. The versatility and applicability to a broad range of substrates make this reaction useful for the development of bioactive derivatives.