33617-67-3

Basic information

• Product Name: 1,3-Dimethoxy-2-(methylthio)benzene
• Synonyms: 1,3-Dimethoxy-2-(methylsulphanyl)benzene, 2,6-Dimethoxythioanisole;2,6-DIMETHOXYBENZENETHIOL;1,3-DIMETHOXY-2-(METHYLTHIO)BENZENE
• CAS NO: 33617-67-3
• Molecular Formula: C₉H₁₂O₂S
• Molecular Weight: 184.26
• Product Categories: Phenyls & Phenyl-Het;Phenyls & Phenyl-Het
• Mol File: 33617-67-3.mol
• Article Data: 6

Chemical Properties

• Melting Point: 79 °C
• Boiling Point: 267.1°Cat760mmHg
• Flash Point: 115.4°C
• Appearance: /
• Density: 1.11g/cm³
• Vapor Pressure: 0.0137mmHg at 25°C
• Refractive Index: 1.543
• CAS DataBase Reference: 1,3-Dimethoxy-2-(methylthio)benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Dimethoxy-2-(methylthio)benzene(33617-67-3)
• EPA Substance Registry System: 1,3-Dimethoxy-2-(methylthio)benzene(33617-67-3)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 33617-67-3(Hazardous Substances Data)

Usage

General Description

1,3-Dimethoxy-2-(methylthio)benzene is a chemical compound with a molecular formula C9H12O2S. It is commonly known as veratrole and is a colorless liquid with a pleasant odor. Veratrole is used in the synthesis of pharmaceuticals, especially in the preparation of various heterocyclic compounds. It is also employed as a flavoring agent in the food industry and as a fragrance component in perfumes and other personal care products. Additionally, veratrole serves as an intermediate in the manufacturing of agrochemicals and dyes. While it has several industrial applications, it is important to handle and store this chemical with caution due to its potentially harmful effects on human health and the environment.

InChI:InChI=1/C9H12O2S/c1-10-7-5-4-6-8(11-2)9(7)12-3/h4-6H,1-3H3

Upstream product

• 75-18-3 dimethylsulfide 
• 151-10-0 1,3-Dimethoxybenzene 
• 624-92-0 Dimethyldisulphide 
• 26163-11-1 2,6-dimethoxybenzenethiol 
• 74-88-4 methyl iodide 
• 101432-08-0 2,2',6,6'-tetramethoxydiphenyl sulfide 
• 214050-07-4 bis(2,6-dimethoxyphenyl) telluride 
• 138616-50-9 bis(2,6-dimethoxyphenyl) selenide 
• 391209-09-9 2,6-dimethoxyphenyl methyl telluride 
• 138616-51-0 2,6-dimethoxyphenyl methyl selenide 
• 391209-08-8 2-ethylselanyl-1,3-dimethoxy-benzene 
• 2734-70-5 2,6-dimethoxyaniline 
• 16932-44-8 2-iodo-1,3-dimethoxybenzene 
• 67-68-5 dimethyl sulfoxide 

Downstream Products

• 38452-16-3 1,3-dimethoxy-2-(methylsulfinyl)benzene 
• 78335-75-8 3-bromo-2,6-dimethoxythioanisole 
• 78335-77-0 2,4-dimethoxy-3-(methylthio)benzaldehyde 
• 78335-76-9 3,5-dimethoxy-4-(methylthio)phenylacetonitrile 
• 78335-78-1 2,4-dimethoxy-3-(methylthio)-β-nitrostyrene 
• 78335-86-1 2-(2,4-Dimethoxy-3-methylsulfanyl-phenyl)-ethylamine 

Relevant articles and documents

Reaction of arynes with sulfoxides

A S-O bond insertion reaction of sulfoxides with arynes is reported. This reaction represents a rare instance of semipolar single bond insertion in aryne chemistry. The study of mechanism indicates that a sulfur ylide triggered by aryne is the key intermediate, which further transfers its methylene group to carbonyl compounds to give epoxides and thioethers through a sequential process.

Method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group

The invention concerns a method for orthometalation of a carbocyclic aromatic derivative bearing at least an electron donor group, characterised in that it consists in reacting said carbocyclic aromatic derivative with an efficient amount of at least one alkaline metal in the presence of a compound of formula (I): RX, wherein: R represents a hydrocarbon radical having 1 to 20 carbon atoms which can be a saturated or unsaturated, linear or branched, acyclic aliphatic radical; a saturated or unsaturated, monocyclic or polycyclic cycloaliphatic radical; a saturated or unsaturated, linear or branched aliphatic radical bearing a cyclic substituent; and X represents a bromine or chlorine atom.

METALLATION - SULFIDATION: A CONVENIENT METHOD FOR THE SYNTHESIS OF ARYL ALKYL SULFIDES AND OF UNSYMMETRICAL DIARYL SULFIDES

-