33619-33-9

Basic information

• Product Name: Acetamide,N,N'-1,5-pentanediylbis[2-chloro-
• Synonyms: Acetamide,N,N'-pentamethylenebis[2-chloro- (7CI,8CI); NSC 58836
• CAS NO: 33619-33-9
• Molecular Formula: C9H16 Cl2 N2 O2
• Molecular Weight: 255.144
• Mol File: 33619-33-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: Acetamide,N,N'-1,5-pentanediylbis[2-chloro-(CAS DataBase Reference)
• NIST Chemistry Reference: Acetamide,N,N'-1,5-pentanediylbis[2-chloro-(33619-33-9)
• EPA Substance Registry System: Acetamide,N,N'-1,5-pentanediylbis[2-chloro-(33619-33-9)

Safety Data

• Hazardous Substances Data: 33619-33-9(Hazardous Substances Data)

Upstream product

• 462-94-2 1,5-diaminopentane 
• 79-04-9 chloroacetyl chloride 
• 4015-58-1 monochloroacetic acid anhydride 
• 96-34-4 methyl chloroacetate 

Relevant articles and documents

Design, synthesis and biological evaluation of organophosphorous-homodimers as dual binding site acetylcholinesterase inhibitors

The cluster effect is an effective strategy to explore new lead compounds, and has been successfully applied in rational drug design and screening. A series of novel organophosphorous-homodimers were designed and synthesized based on the dual-site structure characteristics of acetylcholinesterase (AChE). The compounds were evaluated in vitro for their inhibitory activity to AChE extracted from Drosophila melanogaster and Musca domestic. Compound 4H showed an excellent inhibitor activity to both Drosophila melanogaster and Musca domestic with the corresponding IC50 values of 23 and 168 nM, respectively. Meanwhile, its activities against Drosophila melanogaster and Musca domestic AChE were more than 10,00,000 and 100,000-fold higher compared with the parent compound (MH), and was up to 245 and 107-fold higher than those of the positive control omethoate. The molecular docking study revealed that 4H possessed an optimal spacer length and can perfectly fit into the central pocket, active gorge, and peripheral site of DmAChE, and consequently exhibited highly improved inhibitor potency to DmAChE. The bioassay tests showed that 4 series compounds showed prominent insecticidal activities against both Lipaphser erysimi and Tetranychus cinnbarinus at a concentration of 200 mg/L. The insecticide activity of compound 4H was particularly significant that can cause 96% mortality to Tetranychus cinnbarinus after 24 h of treatment.