33630-46-5

Basic information

• Product Name: 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethannitril
• Synonyms: 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethannitril
• CAS NO: 33630-46-5
• Molecular Weight: 179.175
• Mol File: 33630-46-5.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethannitril(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethannitril(33630-46-5)
• EPA Substance Registry System: 2-Hydroxy-2-(4-hydroxy-3-methoxyphenyl)ethannitril(33630-46-5)

Safety Data

• Hazardous Substances Data: 33630-46-5(Hazardous Substances Data)

Upstream product

• 121-33-5 vanillin 
• 143-33-9 sodium cyanide 
• 74-90-8 hydrogen cyanide 
• 151-50-8 potassium cyanide 

Downstream Products

• 554-52-9 3-Methoxytyramine 
• 2880-58-2 2-methoxy-1,4-benzoquinone 
• 125237-19-6 p,p'-bis(α-cyano(3-methoxy-4-hydroxyphenyl)methylhydrazinocarbonylmethoxy)diphenyl sulphone 
• 83530-82-9 α-(5-o-nitrophenyl-1,3,4-thiadiazol-2-yl-amino)-(4-hydroxy-3-methoxyphenyl)acetonitrile 
• 83530-92-1 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-(4-hydroxy-3-methoxyphenyl)acetonitrile 
• 115353-19-0 (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-(4-hydroxy-3-methoxy-phenyl)-acetonitrile 
• 125803-34-1 Acetic acid (R)-cyano-(4-hydroxy-3-methoxy-phenyl)-methyl ester 
• 129313-30-0 Acetic acid (S)-cyano-(4-hydroxy-3-methoxy-phenyl)-methyl ester 

Relevant articles and documents

PROCESS

A process for the preparation of a compound of formula (I) wherein: R is an alkynyl group; R1 is alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkyl-alkyl, phenyl and phenylalkyl, it being possible in turn for all of the receding groups to carry one or more identical or different halogen atoms; alkoxy; alkenyloxy; alkynyloxy; alkoxyalkyl; haloalkoxy; alkylthio; haloalkylthio; alkysulfonyl; formyl; alkanoyl; hydroxy; halogen; cyano; nitro; amino; alkylamino; dialkylamino; carboxyl; alkoxycarbonyl; alkenyloxycarbonyl; or alkynyloxycarbonyl; and n is an integer from 0 to 3, said process comprising: (i) the reaction of a compound of formula (III) wherein R, R1 and n are as hereinbefore defined; m and m' are independently 0 or 1; when m and m' are both 0, A is an alkyl, alkenyl or alkynyl group (suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when one of m and m' is 0 and the other is 1, A is an alkanediyl, alkenediyl or alkynediyl group containing at least two carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; when m and m' are both 1, A is an alkanetriyl, alkenetriyl or alkynetriyl group containing at least three carbon atoms (and suitably having up to eight carbon atoms), optionally substituted by one or more groups independently selected from halogen, hydroxy, alkoxy, C1-4 dialkylamino or cyano; and wherein if the group A contains three or more carbon atoms, one or more of the carbon atoms may each optionally be replaced with an oxygen atom, provided that there is at least one carbon atom between any two oxygen atoms in the molecule, with a compound of formula (IV) to give a compound of formula (II) wherein R, R1 and n are as hereinbefore defined, and (ii) the reaction of a compound of formula (II) with , wherein L is a leaving group, to give the compound of formula (I) as hereinbefore defined, is disclosed.

Studies on Synthesis and Antimicrobial Evaluation of some New Thiophenol Derivatives

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Preparation and antimicrobial activity of 4-aryl-3-(phenazon-4'-yl)syndnonimine hydrochloride

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