33641-61-1

Basic information

• Product Name: sulphinylbis(diethylamide)
• Synonyms: Sulphinylbis(diethylamide); N,N,N',N'-tetraethylsulfurous diamide
• CAS NO: 33641-61-1
• Molecular Formula: C₈H₂₀N₂OS
• Molecular Weight: 192.3222
• EINECS: 251-613-7
• Mol File: 33641-61-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 281.5°C at 760 mmHg
• Flash Point: 124°C
• Density: 1.041g/cm³
• Vapor Pressure: 0.00356mmHg at 25°C
• Refractive Index: 1.512
• CAS DataBase Reference: sulphinylbis(diethylamide)(CAS DataBase Reference)
• NIST Chemistry Reference: sulphinylbis(diethylamide)(33641-61-1)
• EPA Substance Registry System: sulphinylbis(diethylamide)(33641-61-1)

Safety Data

• Hazardous Substances Data: 33641-61-1(Hazardous Substances Data)

Upstream product

• 109-89-7 diethylamine 
• 30996-04-4 tris(diethylamido)arsenic(III) 
• 34832-65-0 antimony tris(diethylamide) 
• 4773-12-0 diphenyl sulfite 
• 3768-61-4 N,N,N',N'-tetraethylthioamine 

Downstream Products

• 3352-87-2 N,N-diethyldodecanamide 
• 2431-96-1 N,N-diethylphenylacetamide 
• 27829-46-5 (E)-N,N-diethyl-3-phenylacrylamide 
• 95715-61-0 N-N-Dietilcicloesilacetammide 
• 5469-03-4 N-N-Dietilcicloesilpropionammide 
• 57303-20-5 N,N-diethylmyristamide 
• 57303-21-6 NSC 195054 
• 109-89-7 diethylamine 

Relevant articles and documents

Sulfamides and Sulfonamides as Polar Aprotic Solvents

Five tetraalkylsulfamides, one N,N-dialkylsulfonamide, two sulfurous diamides, and one sulfinamide were investigated for potential use as polar aprotic solvents that would be compatible with strongly basic and nucleophilic reagents.The values of Taft β and ?* measured for these compounds indicated that all possess significant polar aprotic solvent character.Their stabilities toward ethylmagnesium bromide, diethylzinc, methyllithium, and butyllithium were determined.Tetraethylsulfamide (Et2NSO2NEt2) and N,N-diethyltrimethylmethanesulfonamide (Me3CSO2NEt2) were the most stable of the solvents, showing no evidence of decomposition with the magnesium or zinc compounds and an appreciable lifetime with methyllithium.

Synthesis, biological evaluation and molecular modeling of substituted indeno[1,2-b]indoles as inhibitors of human protein kinase CK2

Due to their system of annulated 6-5-5-6-membered rings, indenoindoles have sparked great interest for the design of ATP-competitive inhibitors of human CK2. In the present study, we prepared twenty-one indeno[1,2-b]indole derivatives, all of which were tested in vitro on human CK2. The indenoindolones 5a and 5b inhibited human CK2 with an IC50 of 0.17 and 0.61 μM, respectively. The indeno[1,2-b]indoloquinone 7a also showed inhibitory activity on CK2 at a submicromolar range (IC50 = 0.43 μM). Additionally, a large number of indenoindole derivatives was evaluated for their cytotoxic activities against the cell lines 3T3, WI-38, HEK293T and MEF.