33644-25-6 Usage
Description
(2S)-3-fluoropropane-1,2-diol is a chiral chemical compound with the molecular formula C3H7FO2. It is also known by the systematic name (2S)-3-fluoropropane-1,2-diol and the IUPAC name (2S)-2,3-dihydroxy-1-fluoropropane. (2S)-3-fluoropropane-1,2-diol has two stereoisomers, (2S)-3-fluoropropane-1,2-diol and (2R)-3-fluoropropane-1,2-diol, and is widely used as an intermediate in organic synthesis.
Uses
Used in Pharmaceutical Industry:
(2S)-3-fluoropropane-1,2-diol is used as an intermediate in the synthesis of various pharmaceuticals. Its unique structure and properties make it a valuable building block for the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
(2S)-3-fluoropropane-1,2-diol is also used in the production of agrochemicals, contributing to the development of effective and environmentally friendly pesticides and other agricultural products.
Used in Specialty Chemicals Manufacturing:
(2S)-3-fluoropropane-1,2-diol serves as a key component in the manufacturing of specialty chemicals, which are used in a variety of applications, including coatings, adhesives, and other industrial products.
Used in Organic Synthesis:
As a versatile intermediate, (2S)-3-fluoropropane-1,2-diol is used in the synthesis of complex organic molecules, enabling the creation of new compounds with diverse applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 33644-25-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,6,4 and 4 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 33644-25:
(7*3)+(6*3)+(5*6)+(4*4)+(3*4)+(2*2)+(1*5)=106
106 % 10 = 6
So 33644-25-6 is a valid CAS Registry Number.
33644-25-6Relevant articles and documents
Highly selective hydrolytic kinetic resolution of terminal epoxides catalyzed by chiral (salen)CoIII complexes. Practical synthesis of enantioenriched terminal epoxides and 1,2-diols
Schaus, Scott E.,Brandes, Bridget D.,Larrow, Jay F.,Tokunaga, Makoto,Hansen, Karl B.,Gould, Alexandra E.,Furrow, Michael E.,Jacobsen, Eric N.
, p. 1307 - 1315 (2007/10/03)
The hydrolytic kinetic resolution (HKR) of terminal epoxides catalyzed by chiral (salen)CoIII complex 1·OAc affords both recovered unreacted epoxide and 1,2-diol product in highly enantioenriched form. As such, the HKR provides general access to useful, highly enantioenriched chiral building blocks that are otherwise difficult to access, from inexpensive racemic materials. The reaction has several appealing features from a practical standpoint, including the use of H2O as a reactant and low loadings (0.2-2.0 mol %) of a recyclable, commercially available catalyst. In addition, the HKR displays extraordinary scope, as a wide assortment of sterically and electronically varied epoxides can be resolved to ≥ 99% ee. The corresponding 1,2-diols were produced in good-to-high enantiomeric excess using 0.45 equiv of H2O. Useful and general protocols are provided for the isolation of highly enantioenriched epoxides and diols, as well as for catalyst recovery and recycling. Selectivity factors (krel) were determined for the HKR reactions by measuring the product ee at ca. 20% conversion. In nearly all cases, krel values for the HKR exceed 50, and in several cases are well in excess of 200.
