33667-52-6

Basic information

• Product Name: methyl 1-benzhydrylazetidine-2-carboxylate
• Synonyms: methyl 1-benzhydrylazetidine-2-carboxylate;1-Benzhydryl-azetidine-2-carboxylic acid methyl ester;1-(Diphenylmethyl)-2-azetidinecarboxylic acid methyl ester;ethyl N-benzhydryl-2-azetidinecarboxylate;NSC 135858
• CAS NO: 33667-52-6
• Molecular Formula: C₁₈H₁₉NO₂
• Molecular Weight: 281.34896
• Mol File: 33667-52-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 366℃
• Flash Point: 122℃
• Appearance: /
• Density: 1.163
• Vapor Pressure: 1.55E-05mmHg at 25°C
• Refractive Index: 1.592
• Storage Temp.: 2-8°C
• CAS DataBase Reference: methyl 1-benzhydrylazetidine-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 1-benzhydrylazetidine-2-carboxylate(33667-52-6)
• EPA Substance Registry System: methyl 1-benzhydrylazetidine-2-carboxylate(33667-52-6)

Safety Data

• Hazardous Substances Data: 33667-52-6(Hazardous Substances Data)

Usage

General Description

Methyl 1-benzhydrylazetidine-2-carboxylate is a chemical compound with the molecular formula C21H23NO2. It is a azetidine derivative and is often used as a building block in the synthesis of various pharmaceuticals and organic compounds. methyl 1-benzhydrylazetidine-2-carboxylate has been studied for its potential use in medicinal chemistry and drug development, particularly in the design of new drugs with potentially beneficial properties. Its unique molecular structure and properties make it a valuable component in chemical research and development.

InChI:InChI=1/C18H19NO2/c1-21-18(20)16-12-13-19(16)17(14-8-4-2-5-9-14)15-10-6-3-7-11-15/h2-11,16-17H,12-13H2,1H3

Upstream product

• 29547-04-4 methyl 2,4-dibromobutanoate 
• 91-00-9 Benzhydrylamine 

Downstream Products

• 72351-68-9 1-diphenylmethyl-2-hydroxymethylazetidine 
• 130054-77-2 Cyano-acetic acid 1-benzhydryl-azetidin-2-ylmethyl ester 

Relevant articles and documents

Preparation comprising an enzyme for asymmetrical hydrolysis of N-substituted C3-C4 cyclic imino-2-carboxylic acid ester and method of using the same

There is disclosed an enzyme preparation comprising: (i) a styrene-divinylbenzene copolymer having fine pores with an average radius of 200 - 500?, and (ii) an enzyme capable of asymmetrically hydrolyzing N-substituted C3-C4 cyclic imino-2-carboxylic acid ester to preferentially produce an (S)-N-substituted C3-C4 cyclic imino-2-carboxylic acid, wherein said enzyme comprises an amino acid sequence as set forth in SEQ ID NO: 1 or the like.

Novel 2-amino-1,4-dihydropyridine calcium antagonists. II. Synthesis and antihypertensive effects of 2-amino-1,4-dihydropyridine derivatives having N,N-dialkylaminoalkoxycarbonyl groups at 3- and/or 5-positions

Novel 2-amino-1,4-dihydropyridine derivatives I, which contain N,N-dialkylaminoalkoxycarbonyl groups at the 3- and/or 5-position, were synthesized and their antihypertensive effects were evaluated in spontaneously hypertensive rats. Remarkably prolonged duration of antihypertensive action was observed when a tertiary amino group was introduced into either the 3- or 5-ester side-chain of the 1,4-dihydropyridine ring. In particular, the compounds containing cyclic amino moieties at the 3-position showed greater potency than those with acyclic amino moieties. Chemical modification studies indicated that the two ester side-chains of 1,4-dihydropyridine at the 3- and 5-position might function in a different manner in relation to the antihypertensive activities. 3-(1-Benzhydrylazetidin-3-yl) 5-isopropyl 2-amino-1,4-dihydro-6-methyl-4-(3-nitrophenyl)-3,5-pyridine-dicarboxyl ate, I-43 (CS-905), exhibited potent and long-lasting antihypertensive effects with gradual onset of action, and is a promising candidate as an antihypertensive drug.