336881-91-5

Basic information

• Product Name: 4-[4-(2-hydroxyphenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N,N-dimethylbutanamide
• Synonyms: 4-[4-(2-hydroxyphenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N,N-dimethylbutanamide
• CAS NO: 336881-91-5
• Molecular Weight: 458.601
• Mol File: 336881-91-5.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 4-[4-(2-hydroxyphenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N,N-dimethylbutanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[4-(2-hydroxyphenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N,N-dimethylbutanamide(336881-91-5)
• EPA Substance Registry System: 4-[4-(2-hydroxyphenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenyl-N,N-dimethylbutanamide(336881-91-5)

Safety Data

• Hazardous Substances Data: 336881-91-5(Hazardous Substances Data)

Upstream product

• 336882-79-2 1-benzyl-4-(2-benzyloxy-phenyl)-piperidin-4-ol 
• 328000-16-4 (2-(benzyloxy)phenyl)magnesium bromide 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 37743-18-3 N-(dihydro-3,3-diphenyl-2(3H)-furanylidene)-N-methylmethanaminium bromide 
• 336882-80-5 4-hydroxy-4-(2-hydroxyphenyl)piperidine 

Downstream Products

• 336882-26-9 4-(4-hydroxy-4-(2-(6-hydroxyhexyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide 
• 336882-25-8 4-(4-hydroxy-4-(2-(4-hydroxybutyloxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide 
• 336882-16-7 4-(4-hydroxy-4-(2-(3-hydroxypropoxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide 
• 336882-64-5 2-(2-(1-(4-dimethylamino-4-oxo-3,3-diphenylbutyl)-4-hydroxy-4-piperidinyl)phenoxy)acetic acid 
• 336882-17-8 4-{4-hydroxy-4-[2-(2-hydroxy-ethoxy)-phenyl]-piperidin-1-yl}-N,N-dimethyl-2,2-diphenyl-butyramide 
• 336882-14-5 N,N-dimethyl-2,2-diphenyl-4-[4-hydroxy-4-[2-(2-methoxyethoxy)phenyl]piperidin-1-yl]butanamide 
• 336881-95-9 {2-[1-(3-dimethylcarbamoyl-3,3-diphenyl-propyl)-4-hydroxy-piperidin-4-yl]-phenoxy}-acetic acid ethyl ester 
• 336882-05-4 4-(4-hydroxy-4-(2-(3-acetoxypropoxy)phenyl)piperidino)-N,N-dimethyl-2,2-diphenylbutaneamide 
• 336882-04-3 acetic acid 2-{2-[1-(3-dimethylcarbamoyl-3,3-diphenyl-propyl)-4-hydroxy-piperidin-4-yl]-phenoxy}-ethyl ester 
• 336882-13-4 N,N-dimethyl-2,2-diphenyl-4-[4-hydroxy-4-[2-(carbamoylmethoxy)phenyl]piperidin-1-yl]butanamide 
• 412302-31-9 4-[4-(2-hydroxyphenyl)-1,2,3,6-tetrahydropyridin-1-yl]-N,N-dimethyl-2,2-diphenylbutanamide 

Relevant articles and documents

2,2-DIPHENYLBUTANAMIDE DERIVATIVES AND MEDICINES CONTAINING THE SAME

2,2-Diphenylbutanamide derivatives represented by the following formula (1): [wherein A represents -(CH2)n- (n is 1 or 2) or a methine (CH) group; when A is -CH2-, B represents a methine group or a nitrogen atom, with A and B forming a single bond; when A is -(CH2)2-, B represents a nitrogen atom, with A and B forming a single bond; when A is a methine group, B represents a quaternary carbon atom, with A and B forming a double bond; each of R1 and R2, which are identical to or different from each other, represents a hydrogen atom, a lower alkyl group, or a cycloalkyl group, or R1 and R2 may form a heterocyclic ring together with the adjacent nitrogen atom; and Ar represents an optionally substituted phenyl group, bicyclic aromatic ring, monocyclic heterocyclic ring, bicyclic heterocyclic ring, or fluorene group]; or salts of the derivatives. The derivatives or salts thereof exhibit excellent μ-opioid agonist activity and analgesic activity against neuropathic pain, and are useful as medicines such as peripheral analgesic drugs and neuropathic pain relieving drugs.

4-hydroxy-4-phenylpiperidine derivatives and pharmaceuticals containing the same

Described is a 4-hydroxy-4-phenylpiperidine derivative represented by the following formula (1): [wherein, R1and R2are the same or different and each independently represents a hydrogen atom, a lower alkyl, or the like, R3represents a hydrogen atom or a group —(CR4R5)n—Y (in which, R4and R5each represents a hydrogen atom or a lower alkyl group, Y represents a group —COOR6, —CONR7R8, —OR9or —OCOR10(in which R6, R9and R10each independently represents a hydrogen atom, a lower alkyl group, or the like, R7and R8are the same or different and each independently represents a hydrogen atom, a lower alkyl group, or the like), and n stands for 1 to 6)], or salt thereof. The compound exhibits excellent peripheral analgesic action.