33695-62-4

Basic information

• Product Name: Propanenitrile, 2-methyl-2-(phenylthio)-
• CAS NO: 33695-62-4
• Molecular Formula: C10H11NS
• Molecular Weight: 177.27
• Mol File: 33695-62-4.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Propanenitrile, 2-methyl-2-(phenylthio)-(CAS DataBase Reference)
• NIST Chemistry Reference: Propanenitrile, 2-methyl-2-(phenylthio)-(33695-62-4)
• EPA Substance Registry System: Propanenitrile, 2-methyl-2-(phenylthio)-(33695-62-4)

Safety Data

• Hazardous Substances Data: 33695-62-4(Hazardous Substances Data)

Upstream product

• 18992-13-7 2-cyano-2-nitropropane 
• 930-69-8 sodium thiophenolate 
• 851233-80-2 potassium 2-cyano-2-methyl-propanoate 
• 882-33-7 diphenyldisulfane 
• 78-82-0 Isobutyronitrile 
• 19888-77-8 anti-isobutyraldehyde N,N-dimethylhydrazone 
• 931-59-9 benzenesulfenyl chloride 
• 50654-53-0 2-lithio-2-methylpropionitrile 
• 7677-24-9 trimethylsilyl cyanide 
• 138883-72-4 1-(1-Methyl-1-phenylsulfanyl-ethyl)-1H-benzotriazole 
• 857809-74-6 α-phenylsulfanyl-isobutyric acid amide 
• 74-83-9 methyl bromide 
• 5219-61-4 (phenylthio)acetonitrile 
• 78-67-1 2,2'-azobis(isobutyronitrile) 

Downstream Products

• 36674-49-4 α-benzenesulfonyl-isobutyronitrile 
• 63996-66-7 2-methyl-2-(phenylthio)propanal 
• 61737-13-1 (1-Isopropenyl-4-methyl-pentylsulfanyl)-benzene 
• 63996-44-1 2,6-Dimethyl-2-(phenylthio)-heptan-3-ol 

Relevant articles and documents

Transition-metal-free decarboxylative thiolation of stable aliphatic carboxylates

A transition-metal-free decarboxylative thiolation protocol is reported in which primary, secondary, tertiary (hetero)aryl acetates and α-CN substituted acetates undergo the decarboxylative thiolation smoothly, to deliver a variety of functionalized aryl alkyl sulfides in moderate to excellent yields. Aryl diselenides are also amenable substrates for construction of C-Se bonds under the simple and mild reaction conditions. Moreover, the protocol is successfully applied to the late-stage modification of pharmaceutical carboxylates with satisfactory chemoselectivity and functional-group compatibility. This journal is

N-Acylsulfonamide apoptosis promoters

N-Benzoyl arylsulfonamides having the formula Are BCL-X1 inhibitors and are useful for promoting apoptosis. Also disclosed are BCL-X1 inhibiting compositions and methods of promoting apoptosis in a mammal.

Radical-nucleophilic substitution (SRN1) reactions. Part 7. Reactions of aliphatic α-substituted nitro compounds

α-Nitrothiocyanates R2C(SCN)NO2 have been prepared by oxidative addition of thiocyanate anion to nitronate anions and undergo SRN1 substitution reactions by loss of thiocyanate with nitronate anions, phenylsulfinate, azide and p-nitro- and p-chloro-benzenethiolates in dipolar aprotic solvents. 2-Nitro-2-thiocyanatopropane and other 2-substituted-2-nitropropanes [Me2C(X)NO2 with X = I, Br, Cl, NO2, PhSO2] react with thiolates by SRN1 reactions and/or redox reactions to give disulfides by a polar abstraction or chain SET (SET2) mechanisms. The products are dependent on the nucleophilicity of the thiolates, the polarisability of the α-substituent, the solvent and the presence of light catalysis, radical traps or strong electron acceptors. 2-Substituted-2-nitropropanes [Me2C(X)NO2 with X = N3, NO2, CN, p-NO2-C6H4-N=N] undergo SRN1 substitutions with thiolates by loss of nitrite. 2-Substituted-2-nitropropanes Me2C(X)NO2 and thiolates only yield disulfides in methanol due to solvation of the nitro groups.