33698-67-8Relevant articles and documents
172. β-Cleavage of Bis(homoallylic) Potassium Alkoxides. Two-Step Preparation of Propenyl Ketones from Carboxylic Esters. Synthesis of ar-Turmerone, α-Damascone, β-Damascone, and β-Damascenone
Snowden, Roger L.,Linder, Simon M.,Muller, Bernard L.,Schulte, Karl H.
, p. 1858 - 1878 (2007/10/02)
The transformation of 36 bis(homoallylic) alcohols VII to alkenones IX and X via β-cleavage of their potassium alkoxides VIIa in HMPA has been investigated (cf.Scheme 2).These studies have established an order of β-cleavage for 2-propenyl, 1-methyl-2-propenyl, 2-methyl-2-propenyl, 1,1-dimethyl-2-propenyl, and benzyl groups in alkoxides 49a-56a and have allowed a comparison between the β-cleavage reaction and the oxy-Cope rearrangement in alkoxides 74a-83a.As illustrative synthetic applications, a two-step preparation of propenyl ketones 15-42 from carboxylic esters is described, together with syntheses of ar-turmerone (48), α-damascone ((E)-71), β-damascone ((E)-109), and β-damascenone ((E)-111).
CONDENSATION DES ORGANOMAGNESIENS SUR LES CHLORUSES D'ACIDE DANS LE TETRAHYDROFURANNE A BASSE TEMPERATURE
Dubois, Jacques-Emile,Lion, Claude,Arouisse, Abdelmajid
, p. 1083 - 1088 (2007/10/02)
The condensation of a Grignard reagents with hindered acid chlorides in THF at low temperature, yields ketones which are generally difficult to obtain and avoids the side reaction caused with a CuCl catalyst.Applied to unsaturated Grignard reagents and acid chlorides, this method also yields unsaturated ketones, such as the Artemisia ketone.
