337-03-1 Usage
Description
Flugestone is a synthetic progestogen, a type of hormone that belongs to the group of sex hormones called progestogens. It is chemically related to progesterone and is used in various medical applications due to its hormone-like effects.
Uses
Used in Pharmaceutical Industry:
Flugestone is used as a progestogen for various medical applications, including hormone regulation and treatment of certain conditions related to the reproductive system.
Used in Veterinary Medicine:
In the veterinary field, Flugestone is used as intravaginal sponges for the treatment of certain reproductive issues in animals, particularly horses. It helps in managing the reproductive cycle and improving fertility.
Used in Equine Chorionic Gonadotropins:
Flugestone is also utilized in the production of equine chorionic gonadotropins (eCG), which are hormones that play a crucial role in the reproductive process of horses. The hormone is used to induce ovulation and synchronize estrous cycles, enhancing the overall reproductive efficiency in equine practices.
Check Digit Verification of cas no
The CAS Registry Mumber 337-03-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,3 and 7 respectively; the second part has 2 digits, 0 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 337-03:
(5*3)+(4*3)+(3*7)+(2*0)+(1*3)=51
51 % 10 = 1
So 337-03-1 is a valid CAS Registry Number.
InChI:InChI=1/C21H29FO4/c1-12(23)20(26)9-7-15-16-5-4-13-10-14(24)6-8-18(13,2)21(16,22)17(25)11-19(15,20)3/h10,15-17,25-26H,4-9,11H2,1-3H3/t15-,16-,17-,18-,19-,20-,21?/m0/s1
337-03-1Relevant articles and documents
Preparation method of flurogestone acetate
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Paragraph 0013; 0014; 0015, (2017/12/13)
The invention discloses a preparation method of flurogestone acetate. The preparation method comprises the following steps: using 9a-cortisone bifluoride as a raw material, dissolving 9a-cortisone bifluoride into an organic solvent, and reacting with acyl chloride under the existence of an acid-binding agent to obtain a 9a-cortisone bifluoride-21-O-ester; then reacting the ester with sodium iodide and a sulfur-containing reducing agent in the organic solvent for deesterification, and synthesizing flugestone; and finally reacting the flugestone with acetylchloride or acetic anhydride in the organic solvent, and synthesizing flurogestone acetate. According to the preparation method, 9a-cortisone bifluoride is used as the raw material, flurogestone acetate is synthesized through three-step reaction of 21-site esterification, then reduction and de-esterification and finally 17-site ethyl esterification, and compared with a traditional synthetic method for using a mold removal object acquired through diosgenin processing as a raw material, the preparation method has the advantages such as wide raw material source, short synthetic route, simple, convenient and environmentally-friendly process, few invested equipment and high product yield, and the production cost in the method is reduced by 25% to 30% as compared with a traditional method; and a solvent used in the production can be recycled and circularly used, and is easy for industrial production.