337512-10-4

Basic information

• Product Name: 3-(4-CHLOROPHENYL)-3-OXO-2-(2-PHENYLHYDRAZONO)PROPANAL
• Synonyms: 3-(4-CHLOROPHENYL)-3-OXO-2-(2-PHENYLHYDRAZONO)PROPANAL;(2E)-3-(4-chlorophenyl)-3-oxo-2-(2-phenylhydrazin-1-ylidene)propanal
• CAS NO: 337512-10-4
• Molecular Formula: C₁₅H₁₁ClN₂O₂
• Molecular Weight: 286.71
• Mol File: 337512-10-4.mol
• Article Data: 2

Chemical Properties

• Melting Point: 136-138 °C(Solv: acetonitrile (75-05-8))
• Boiling Point: 446.5±47.0 °C(Predicted)
• Appearance: /
• Density: 1.24±0.1 g/cm3(Predicted)
• PKA: 6.19±0.10(Predicted)
• CAS DataBase Reference: 3-(4-CHLOROPHENYL)-3-OXO-2-(2-PHENYLHYDRAZONO)PROPANAL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(4-CHLOROPHENYL)-3-OXO-2-(2-PHENYLHYDRAZONO)PROPANAL(337512-10-4)
• EPA Substance Registry System: 3-(4-CHLOROPHENYL)-3-OXO-2-(2-PHENYLHYDRAZONO)PROPANAL(337512-10-4)

Safety Data

• Hazardous Substances Data: 337512-10-4(Hazardous Substances Data)

Upstream product

• 100-34-5 benzene diazonium chloride 
• 67382-35-8 (2E)-3-(dimethylamino)-1-(4-chlorophenyl)prop-2-en-1-one 
• 62-53-3 aniline 

Downstream Products

• 4410-31-5 (RS)-mandelamide 
• 3306-06-7 (1RS,2SR)-2-amino-1-phenyl-propane-1,3-diol 
• 50610-93-0 (1RS,2SR)-2-benzoylamino-1-phenyl-propane-1,3-diol 
• 3313-16-4 (1RS,2SR)-2-benzoylamino-1,3-bis-benzoyloxy-1-phenyl-propane 
• 1055324-47-4 6-p-chlorobenzoyl-2-phenyl-2,3-dihydropyridazine-4-carbonitrile 

Relevant articles and documents

Arylhydrazonals as the aldehyde component in Baylis-Hillman reactions

Arylhydrazonals were added to acrylonitrile or methyl vinyl ketone in the presence of DABCO or benzotriazole to yield the intermediate Baylis-Hillman adduct that cyclized under the reaction conditions with water elimination to yield dihydropyridazines. A pyridazine reacted with DMAD to yield a pyridine via a [4+2] Diels-Alder addition followed by retro Diels-Alder elimination of methylene aniline. Two pyridazines were condensed with DMFDMA to yield the corresponding enaminones that reacted with NH2NH2 to afford the pyrazolylpyridazines.