33755-46-3

Basic information

• Product Name: 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate
• Synonyms: 9-fluoro-11beta,17,21-trihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione 17-valerate;Dexamethasonevalerate;DXMvalerate;Dexamethasone-17-valerate;DV 17;Pregna-1,4-diene-3,20-dione, 9-fluoro-11,21-dihydroxy-16-methyl-17-[(1-oxopentyl)oxy]-, (11β,16α)-;Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 17-valerate (8CI);9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate
• CAS NO: 33755-46-3
• Molecular Formula: C₂₇H₃₇FO₆
• Molecular Weight: 476.5774832
• EINECS: 251-669-2
• Mol File: 33755-46-3.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 607.5 °C at 760 mmHg
• Flash Point: 321.2 °C
• Appearance: /
• Density: 1.1174 (estimate)
• Vapor Pressure: 7.72E-17mmHg at 25°C
• Refractive Index: 1.56
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate(CAS DataBase Reference)
• NIST Chemistry Reference: 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate(33755-46-3)
• EPA Substance Registry System: 9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate(33755-46-3)

Safety Data

• Hazardous Substances Data: 33755-46-3(Hazardous Substances Data)

Usage

Description

9-Fluoro-11b,17,21-trihydroxy-16a-methylpregna-1,4-diene-3,20-dione 17-valerate, also known as Dexamethasone Valerate, is a synthetic glucocorticoid derivative. It is characterized by its potent anti-inflammatory and immunosuppressive properties, which are attributed to its ability to modulate various cellular processes, including the inhibition of certain enzymes and the regulation of gene expression.

Uses

Used in Pharmaceutical Industry:
Dexamethasone Valerate is used as an anti-inflammatory agent for the treatment of various conditions characterized by inflammation and immune system overactivity. It is particularly effective in managing conditions such as rheumatoid arthritis, asthma, and allergies due to its ability to suppress the immune response and reduce inflammation.
Used in Dermatological Applications:
In the dermatological field, Dexamethasone Valerate is used as a topical treatment for various skin conditions, including eczema, psoriasis, and contact dermatitis. Its anti-inflammatory and immunosuppressive properties help to alleviate itching, redness, and swelling associated with these conditions.
Used in Ophthalmic Applications:
Dexamethasone Valerate is also utilized in ophthalmology as a treatment for eye inflammation and conditions such as uveitis, iritis, and postoperative inflammation following ocular surgery. Its potent anti-inflammatory effects help to reduce swelling and discomfort in the affected eye.
Used in Veterinary Medicine:
In veterinary medicine, Dexamethasone Valerate is employed to treat inflammatory conditions in animals, similar to its use in humans. It is particularly useful in managing conditions such as allergic reactions, skin inflammation, and postoperative inflammation in pets.
Used as an Impurity Reference:
Dexamethasone Valerate (Betamethasone Valerate EP Impurity C) serves as an impurity reference for Dexamethasone (D298800) in the pharmaceutical industry. It is used to ensure the quality and purity of Dexamethasone products by providing a reference standard for impurity testing and analysis.

Therapeutic Function

Corticosteroid

InChI:InChI=1/C27H37FO6/c1-5-6-7-23(33)34-27(22(32)15-29)16(2)12-20-19-9-8-17-13-18(30)10-11-24(17,3)26(19,28)21(31)14-25(20,27)4/h10-11,13,16,19-21,29,31H,5-9,12,14-15H2,1-4H3/t16-,19+,20+,21+,24+,25+,26+,27+/m1/s1