3377-72-8Relevant articles and documents
Copper-Catalyzed Direct C2-Benzylation of Indoles with Alkylarenes
Zhang, Hui-Jun,Su, Feng,Wen, Ting-Bin
, p. 11322 - 11329 (2015)
The copper-catalyzed regioselective cross-dehydrogenative coupling of N-pyrimidylindoles with benzylic C(sp3)-H bonds has been developed. Di-tert-butyl peroxide was employed as a mild oxidant, and benzaldehyde proved to be an effective additive. This reaction provides a direct and pratical route to a variety of 2-benzylindoles.
Method for synthesizing 2-substituted indole derivative under catalysis of copper
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Paragraph 0035-0038, (2021/09/11)
The invention relates to a method for synthesizing a 2-substituted indole derivative under the catalysis of copper, which comprises the following step of: reacting by taking copper acetylacetonate (Cu (acac) 2) as a catalyst and taking indole and halogenated hydrocarbon as raw materials to obtain the 2-substituted indole derivative. Compared with the prior art, the method has the advantages that the copper acetylacetonate Cu (acac) 2 which is low in price, easy to obtain and stable in property is used as the catalyst, the method is green and economical, the catalyst is used for catalyzing the indole and halogenated hydrocarbon to react to synthesize the 2-substituted indole derivative, the reaction condition is mild, and the selectivity and yield of the product are high; and the synthesis method is simple and green, the 2-substituted indole derivative is directly constructed by using cheap and easily available raw materials indole and halogenated hydrocarbon, and the 2-substituted indole derivative has good substrate universality and has wide application value in the fields of pharmaceutical chemistry, fine chemical industry and the like.
Protocols for the Syntheses of 2,2′-Bis(indolyl)arylmethanes, 2-Benzylated Indoles, and 5,7-Dihydroindolo[2,3- b]carbazoles
Lafzi, Ferruh,Kilic, Haydar,Saracoglu, Nurullah
, p. 12120 - 12130 (2019/10/11)
The electrophilic substitution reaction of 4,7-dihydroindole with aryl-aldehydes as an electrophilic partner followed by an oxidation step to deliver 2,2′-bis(indolyl)arylmethanes was studied for the first time. The reaction afforded regioselectivity at the 2,2′-positions of indole in an operationally simple and inexpensive procedure with a variety of substrates. To the best of our knowledge, this is the first set of examples of 2,2′-bis(indolyl)arylmethanes obtained in a substituent-free manner. A facile method from dipyrromethanes to the corresponding 2-benzylindoles was also reported. In addition, 2,2′-bis(indolyl)arylmethanes were converted to 5,7-dihydroindolo[2,3-b]carbazoles.
