3377-74-0Relevant articles and documents
Nickel-catalyzed C3-alkylation of indoles with alcohols: Via a borrowing hydrogen strategy
Hu, Miao,Jiang, Yong,Sun, Nan,Hu, Baoxiang,Shen, Zhenlu,Hu, Xinquan,Jin, Liqun
, p. 10057 - 10062 (2021/06/15)
An efficient method for the Ni-catalyzed C3-alkylation of indoles using readily available alcohols as the alkylating reagents has been developed. The alkylation was addressed with an air and moisture-stable binuclear nickel complex ligated by tetrahydroquinolin-8-one as the effective pre-catalyst. The newly developed transformation could accommodate a broad substrate scope including primary/secondary benzylic and aliphatic alcohols and substituted indoles. Mechanistic studies suggested that the reaction proceeds through a borrowing hydrogen pathway.
Highly diastereoselective oxa-[3+3] cyclization with C,N-cyclic azomethine imines: Via the copper-catalyzed aerobic oxygenated CC bond of indoles
Yu, Lemao,Zhong, Yuan,Yu, Jicong,Gan, Lu,Cai, Zhengjun,Wang, Rui,Jiang, Xianxing
supporting information, p. 2353 - 2356 (2018/03/09)
Herein, a copper-catalyzed highly diastereoselective aerobic oxygenated [3+3] cyclization of 3-substituted indoles with C,N-cyclic azomethine imines using oxygen as the sole oxidant under mild conditions has been developed. This protocol provides a simple and convenient approach for constructing [2,3]-fused indoline O-heterocycles bearing two pharmaceutically intriguing parts, tetrahydroisoquinoline and indoline. Good yields and excellent diastereoselectivity under mild reaction conditions were observed.
Iron-catalyzed tandem cyclization and cross-coupling reactions of iodoalkanes and aryl grignard reagents
Kim, Jae Gon,Son, Young Hoon,Seo, Jin Won,Kang, Eun Joo
supporting information, p. 1781 - 1789 (2015/05/27)
A range of arylmethyl-substituted pyrrolidines and tetrahydrofurans were produced by FeCl2-catalyzed tandem cyclization and cross-coupling reactions of alkyl iodides and aryl Grignard reagents. The substituents on alkenes had a profound effect
