33829-10-6

Basic information

• Product Name: 2H-Indol-2-one, 1,3-dihydro-3-(1-naphthalenylimino)-
• CAS NO: 33829-10-6
• Molecular Formula: C18H12N2O
• Molecular Weight: 272.30100
• Mol File: 33829-10-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2H-Indol-2-one, 1,3-dihydro-3-(1-naphthalenylimino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2H-Indol-2-one, 1,3-dihydro-3-(1-naphthalenylimino)-(33829-10-6)
• EPA Substance Registry System: 2H-Indol-2-one, 1,3-dihydro-3-(1-naphthalenylimino)-(33829-10-6)

Safety Data

• Hazardous Substances Data: 33829-10-6(Hazardous Substances Data)

Upstream product

• 91-56-5 indole-2,3-dione 
• 134-32-7 1-amino-naphthalene 

Downstream Products

• 202645-00-9 C₄₆H₃₂N₂O₃ 

Relevant articles and documents

Synthesis, biological activity and docking study of some new isatin Schiff base derivatives

A set of novel Schiff bases of isatin were synthesized and characterized by reaction of isatin with various aromatic or heterocyclic primary amines. Cytotoxic activities for some of the synthesized compounds were evaluated byMTTassay in three human cancer cell lines (HeLa, LS180 and Raji). Half of the tested compounds showed good cytotoxicity in HeLa cells. 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one was found to be the most potent molecule among the studied isatin derivatives. Docking studies of 3-substituted indolin-2-one scaffolds on vascular endothelial growth factor receptor 2 (VEGFR-2) involved in cell proliferation and angiogenesis was performed. 3-(naphthalen-1-ylimino) indolin-2-one and 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one exhibited higher docking binding energies with receptor. For 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one, H-bond interaction with Cys917 residue of target active site was in common with reported crystallographic benzoimidazole derivative (PDB code: 2OH4). New key H-bonds involving Glu915, Asn921, and Arg1049 residues in VEGFR-2 active site could be detected for 3-(2-(4-nitrophenyl) hydrazono) indolin-2-one. Extended lipophilic rings containing H-bond acceptors on the 3 position of indoline scaffold seemed to be important factors in developing potent VEGFR-2 inhibitors virtually. Based on the ligand efficiency indices, some isoxazole or thiazole substituted isatin derivatives may be regarded as efficient candidates for further molecular developments of anticancer agents. Springer Science+Business Media, LLC 2011.

A novel route to anticonvulsant imesatins and an approach to cryptolepine, the alkaloid from Cryptolepis Sp.

Interesting products having anticonvulsant properties are synthesized from solution phase dielectric heating of isatin and aromatic amines and diamines without any catalyst and an approach to cryptolepine skeleton is made from one of them. In addition, th