33859-00-6

Basic information

• Product Name: N-[(E)-(3,4-dimethoxyphenyl)methylidene]-1-phenylmethanamine
• CAS NO: 33859-00-6
• Molecular Formula: C₁₆H₁₇NO₂
• Molecular Weight: 255.3117
• Mol File: 33859-00-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 379.8°C at 760 mmHg
• Flash Point: 148.7°C
• Density: 1.02g/cm³
• Vapor Pressure: 1.25E-05mmHg at 25°C
• Refractive Index: 1.527
• CAS DataBase Reference: N-[(E)-(3,4-dimethoxyphenyl)methylidene]-1-phenylmethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-[(E)-(3,4-dimethoxyphenyl)methylidene]-1-phenylmethanamine(33859-00-6)
• EPA Substance Registry System: N-[(E)-(3,4-dimethoxyphenyl)methylidene]-1-phenylmethanamine(33859-00-6)

Safety Data

• Hazardous Substances Data: 33859-00-6(Hazardous Substances Data)

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 100-46-9 benzylamine 

Downstream Products

• 13174-24-8 N-benzyl-N-(3,4-dimethoxybenzyl)amine 
• 135473-56-2 [Benzylamino-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester 
• 206125-93-1 2-[Benzyl-(3,4-dimethoxy-benzyl)-amino]-1-(4-methoxy-phenyl)-ethanone 
• 109522-07-8 (S)-2-amino-3-(3,4-dimethoxyphenyl)-2-methylpropionamide 
• 111793-96-5 (3S,4R)-1-benzyl-3-methyl-3-<2-oxo-(4S)-phenyloxazolidinyl>-4-(3,4-dimethoxyphenyl)azetidin-2-one 
• 555-30-6 methyldopa 
• 944416-37-9 (S)-2-amino-3-(3,4-dimethoxyphenyl)-N-methyl-propionamide 
• 107395-15-3 amino-(3,4-dimethoxyphenyl)methane phosphonic acid 
• 135473-62-0 [Amino-(3,4-dimethoxy-phenyl)-methyl]-phosphonic acid diethyl ester 
• 774539-01-4 2,6-dichloro-4,8-di-(N-benzyl-N-3',4'-dimethoxybenzylamino)pyrimido[5,4-d]pyrimidine 
• 774539-15-0 2,6-bis(diethanoloamino)-4,8-di-(N-benzyl-N-3',4'-dimethoxybenzylamino)pyrimido[5,4-d]pyrimidine 

Relevant articles and documents

Sequential Cu(I)/Pd(0)-catalyzed multicomponent coupling and annulation Protocol for the synthesis of indenoisoquinolines

Copper-catalyzed coupling of imines, vinylstannanes, or alkynes and o-bromoaroyl chlorides followed by Pd(0)-catalyzed annulations afforded indenoisoquinolines. Protocols requiring minimal purifications were developed, providing new methods for the construction of combinatorial libraries.

Simple synthetic equivalents for the β-(N,N-disubstituted)ethylamino acyl cation synthon and their applications

Various N,N-disubstituted-β-amino-N-methoxy-N-methylpropanamides 3a-i were prepared which served as an excellent β-aminoacyl cation equivalents. These were used to prepare β-amino ketones 1, pharmacologically active tertiary 1-(3,3-diarylpropyl)amines 7a-c, and the interesting C-glycoside 8.

Synthesis of 7,12-dihydro-12-phenyl-5H-6,12-methanodibenz[cf]azocines via N,N-dibenzylphenacylamines

N,N-DibenzyIphenacylamines (1) were prepared in high yields by a onepot reaction and cyclized at room temperature to give 7,12-dihydro-12-phenyl-5H-6,12-methanodibenz[cf]azocines in high yields. 95% H2SO4 or 70% HClO4 was used as cyclization catalysts. The double-cyclization proceeds smoothly in the cases where electron-donating groups are present in both benzene ring. N-2,3-dimethoxybenzyl-N-benzylphenacylamine (If) gave the corresponding N-benzyl-1,2-dihydro-4-phenylisoquinoline on treatment with 95% H2SO4 while N-3,4-Dimethoxybenzyl-N-benzylphenacylamine (1a) at the same reaction conditions and reaction time cyclized to the corresponding dibenzazocine. However la gave the corresponding dihydroisoquinoline which disproportionates to give N-benzyl-1,2,3,4-tetrahydro-4-phenylisoquinoline and N-benzyl-4-phenylisoquinolinium when treated with 70% perchloric acid at room temperature.