33863-79-5

Basic information

• Product Name: N-(4-chlorobenzyl)-4-methylbenzeneamine
• Synonyms: N-(4-chlorobenzyl)-4-methylbenzeneamine
• CAS NO: 33863-79-5
• Molecular Weight: 231.725
• Mol File: 33863-79-5.mol
• Article Data: 26

Chemical Properties

• CAS DataBase Reference: N-(4-chlorobenzyl)-4-methylbenzeneamine(CAS DataBase Reference)
• NIST Chemistry Reference: N-(4-chlorobenzyl)-4-methylbenzeneamine(33863-79-5)
• EPA Substance Registry System: N-(4-chlorobenzyl)-4-methylbenzeneamine(33863-79-5)

Safety Data

• Hazardous Substances Data: 33863-79-5(Hazardous Substances Data)

Upstream product

• 15485-32-2 N-(4-chlorobenzylidene)-4-toluidine 
• 5398-09-4 4-tolyl benzenesulfonate 
• 104-86-9 4-chlorobenzylamine 
• 3899-96-5 4-methylphenyl tosylate 
• 37100-89-3 4-chloro-benzenesulfonic acid p-tolyl ester 
• 321578-69-2 4-tolyl 4-nitrobenzenesulfonate 
• 106-49-0 p-toluidine 
• 104-83-6 1-Chloro-4-(chloromethyl)benzene 
• 99-99-0 1-methyl-4-nitrobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 33442-36-3 (E)-1-(4-chlorophenyl)-N-(p-tolyl)methanimine 
• 623-03-0 4-Cyanochlorobenzene 
• 74-11-3 para-chlorobenzoic acid 
• 2447-95-2 4-chloro-N-(4-tolyl)benzamide 

Downstream Products

• 15485-32-2 N-(4-chlorobenzylidene)-4-toluidine 
• 1145685-67-1 diethyl {(4-chlorophenyl)[(4-tolyl)amino]methyl}phosphonate 
• 123-11-5 4-methoxy-benzaldehyde 
• 104-88-1 4-chlorobenzaldehyde 
• 118051-91-5 N-(4-chlorobenzyl)-N-(2-cyanoethyl)-4-methylaniline 
• 127598-95-2 N-benzyl N-(4-chlorobenzyl)-4-methylaniline 

Relevant articles and documents

Photocatalytic Water-Splitting Coupled with Alkanol Oxidation for Selective N-alkylation Reactions over Carbon Nitride

Photocatalytic water splitting technology (PWST) enables the direct use of water as appealing “liquid hydrogen source” for transfer hydrogenation reactions. Currently, the development of PWST-based transfer hydrogenations is still in an embryonic stage. Previous reports generally centered on the rational utilization of the in situ generated H-source (electrons) for hydrogenations, in which photogenerated holes were quenched by sacrificial reagents. Herein, the fully-utilization of the liquid H-source and holes during water splitting is presented for photo-reductive N-alkylation of nitro-aromatic compounds. In this integrate system, H-species in situ generated from water splitting were designed for nitroarenes reduction to produce amines, while alkanols were oxidized by holes for cascade alkylating of anilines as well as the generated secondary amines. More than 50 examples achieved with a broad range scope validate the universal applicability of this mild and sustainable coupling approach. The synthetic utility of this protocol was further demonstrated by the synthesis of existing pharmaceuticals via selective N-alkylation of amines. This strategy based on the sustainable water splitting technology highlights a significant and promising route for selective synthesis of valuable N-alkylated fine chemicals and pharmaceuticals from nitroarenes and amines with water and alkanols.

Manganese-Catalyzed Transfer Hydrogenation of Aldimines

The reduction of imines to amines via transfer hydrogenation was achieved promoted by phosphine-free manganese(I) catalyst. Using isopropanol as reductant, in the presence of tBuOK (4 mol %) and manganese complex [Mn(CO)3Br(κ2N,N-PyCH2NH2)] (2 mol %), a large variety of aldimines (30 examples) were typically reduced in 3 hours at 80 °C with good to excellent yield.

Application of a catalyst-free Domino Mannich/Friedel-Crafts alkylation reaction for the synthesis of novel tetrahydroquinolines of potential antitumor activity

A useful and efficient method to construct diversely substituted 1,2,3,4-tetrahydroquinolines in good to excellent yields has been developed through a catalyst-free Domino Mannich and intramolecular Friedel-Crafts alkylation reactions of N-arylamines with