33868-76-7

Basic information

• Product Name: 1-(4-METHOXY-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE
• Synonyms: 1-(4-METHOXY-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE
• CAS NO: 33868-76-7
• Molecular Formula: C₁₂H₁₄O₂S₂
• Molecular Weight: 255.3763
• Mol File: 33868-76-7.mol
• Article Data: 23

Chemical Properties

• Melting Point: 90 °C(Solv: chloroform (67-66-3); hexane (110-54-3))
• Boiling Point: 387.366°C at 760 mmHg
• Flash Point: 187.493°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.589
• CAS DataBase Reference: 1-(4-METHOXY-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(4-METHOXY-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE(33868-76-7)
• EPA Substance Registry System: 1-(4-METHOXY-PHENYL)-3,3-BIS-METHYLSULFANYL-PROPENONE(33868-76-7)

Safety Data

• Hazardous Substances Data: 33868-76-7(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Tetrahedron Letters, 14, p. 4207, 1973 DOI: 10.1016/S0040-4039(01)87150-1

InChI:InChI=1/C12H14O2S2/c1-14-10-6-4-9(5-7-10)11(13)8-12(15-2)16-3/h4-8H,1-3H3

Upstream product

• 41501-69-3 3,3-dichloro-1-(4-methoxyphenyl)-2-propen-1-one 
• 5188-07-8 sodium thiomethoxide 
• 75-15-0 carbon disulfide 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 74-88-4 methyl iodide 
• 33895-75-9 N,N-Dimethyl-bis-3,3-(methylthio)-propen⁽²⁾-iminium⁽¹⁾-iodid 
• 30162-62-0 3-Cyclohexylamino-3-p-methoxyphenylpropen-methyldithioat 
• 21262-53-3 3-Benzylamino-3-(4-methoxy-phenyl)-propen-⁽²⁾-dithiosaeure-methylester 
• 32316-81-7 (Z)-3-Dimethylamino-3-(4-methoxy-phenyl)-dithioacrylic acid methyl ester 
• 32470-65-8 5-(4-Methoxyphenyl)-3-(methylthio)-1,2-dithiolium-iodid 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 50267-90-8 Methyl (3-Methylthio)-3-(4-methoxyphenyl)-2-propenedithioate (Z-isomer) 
• 76369-35-2 4-(4-Methoxy-phenyl)-6-morpholin-4-yl-pyrimidin-2-ylamine 
• 116830-58-1 2-(4-Methoxy-phenyl)-1-(3-methyl-isoxazol-5-yl)-4,4-bis-methylsulfanyl-but-3-en-2-ol 
• 113200-38-7 2-(4-Methoxy-phenyl)-4,4-bis-methylsulfanyl-1-pyridin-2-yl-but-3-en-2-ol 
• 78570-47-5 2-(4-methoxyphenyl)-4-(methylthio)-5,6,7,8-tetrahydroquinoline 
• 132058-95-8 3-(4-methoxybenzoyl)-2,5-diphenylpyrrole 
• 130001-02-4 (E)-2-<(4-methoxybenzoyl)methylene>-4,4-dimethyl-oxazolidine 
• 128951-27-9 4-(4-Methoxy-phenyl)-6-methylsulfanyl-pyran-2-one 
• 107195-10-8 2-(imidazolidin-2-ylidene)-1-(4-methoxyphenyl)ethan-1-one 
• 107165-84-4 1-(4-methoxyphenyl)-2-(tetrahydropyrimidin-2(1H)-ylidene)ethan-1-one 
• 124927-45-3 2-(1,3-diazepan-2-ylidene)-1-(4-methoxyphenyl)ethan-1-one 
• 19959-65-0 1,1-Bis-anilino-3-(4-methoxy-phenyl)-propen-⁽¹⁾-on-⁽³⁾ 
• 76369-25-0 (Z)-1-(4-Methoxy-phenyl)-3-methylsulfanyl-3-phenylamino-propenone 
• 67259-55-6 2-methylthio-4-(p-methoxyphenyl)-3H-1,5-benzodiazepine 

Relevant articles and documents

Synthesis of 2,4,5-Trisubstituted Oxazoles with Complementary Regioselectivity from α-Oxoketene Dithioacetals and β-(Methylthio)-β-(het)aryl-2-propenones

An efficient protocol for the synthesis of 2,5-substituted 4-acyloxazoles and the related 2,4-substituted 5-acyloxazoles with complementary regioselectivity from the corresponding α-oxoketene dithioacetals or β-(het)aryl/(methylthio)enone precursors has been reported. In the first protocol, the α-oxoketene dithioacetals or β-(methylthio)enones were converted to the corresponding α-bromo-β-(methylthio)enones followed by copper catalyzed inter/intramolecular annulation of these intermediates with various primary amides affording 2-(het)aryl/alkyl-4-(het)aroyl-5-(methylthio)/(het)aryloxazoles via concomitant formation of the C4-N and C5-O bond via enamide intermediates. In the second approach, the starting α-oxoketene dithioacetals or β-(methylthio)-β-(het)arylenones were subjected to base induced conjugate addition-elimination with various primary amides to furnish β-aroylenamides, which, on subsequent iodine catalyzed intramolecular oxidative C-H functionalization/C-O bond formation, afforded the corresponding regioisomeric 2-(het)aryl/alkyl-4-(methylthio)/(het)aryl-5-(het)aroyloxazoles in excellent yields. The methodology has also been extended for the synthesis of regioisomeric 4- or 5-aminooxazoles and 4- or 5-(n-butyl)oxazoles from the corresponding 4- or 5-(methylthio)oxazoles.

HETERO RING-FUSED PHENYL COMPOUNDS FOR INHIBITING TNIK AND MEDICAL USES THEREOF

The present disclosure provides the compound having inhibitory property against TNIK having a specific chemical structure or its pharmaceutically acceptable salt. The present disclosure also provides a composition comprising the compound or its pharmaceutically acceptable salt. The present disclosure also provides a medical use of the compound, its salt or the composition comprising the compound or its pharmaceutically acceptable salt for treating or preventing cancer. The present disclosure also provides a method of treatment or prevention of cancer comprising administering the compound, its salt or the composition comprising the compound or its salt to a subject in need of such treatment or prevention.

Synthesis and molecular docking studies of novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives: Using ring-opening reactions of cyclic ketene-N,O-acetal

A series of six novel 2-(2-amino-6-phenyl-4-pyrimidinylamino) ethanol derivatives have been synthesized starting from commercially available substituted acetophenones via Oxoketene Dithioacetals with high yields. Ketene dithioacetal store act with 2-amino