33879-72-0Relevant articles and documents
BENZIMIDAZOLONE DERIVED INHIBITORS OF BCL6
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Paragraph 00372, (2018/12/13)
The present invention relates to compounds of Formula I that function as inhibitors of BCL6 (B-cell lymphoma 6) activity: wherein X1, X2, R1, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of proliferative disorders, such as cancer, as well as other diseases or conditions in which BCL6 activity is implicated.
Mutation and inhibition studies of mevalonate 5-diphosphate decarboxylase
Qiu, Yongge,Gao, Jinbo,Guo, Fei,Qiao, Yuqin,Li, Ding
, p. 6164 - 6168 (2008/04/03)
Mevalonate 5-diphosphate decarboxylase plays an important role in regulating cholesterol biosynthesis, which was studied through incubation with various synthetic substrate analogs and characterization of mutated enzymes. The results are potentially useful for further developing inhibitors that block the mevalonate pathway which is a drug target for treating cardiovascular disease and cancer.