33889-68-8 Usage
Description
Demethyl tetrandrine is an alkaloid compound isolated from the plant Thalictrum rugosum Ait, which exhibits dextrorotatory properties with a specific rotation of [α]D +128° (MeOH). It has a unique ultraviolet spectrum, featuring a single absorption maximum at 283 nm.
Uses
Used in Pharmaceutical Industry:
Demethyl tetrandrine is used as an anti-cancer agent for its ability to inhibit breast adenocarcinoma proliferation through the induction of apoptosis. This makes it a promising candidate for the development of cancer treatments, particularly for breast cancer.
Additionally, Demethyl tetrandrine is used as an antiviral agent for its demonstrated ability to inhibit HIV-Type 1 replication. This application can contribute to the development of new therapeutic strategies for managing and treating HIV infections.
References
Mitscher et al., Chem. Commun., 589 (1971)
Check Digit Verification of cas no
The CAS Registry Mumber 33889-68-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,8,8 and 9 respectively; the second part has 2 digits, 6 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 33889-68:
(7*3)+(6*3)+(5*8)+(4*8)+(3*9)+(2*6)+(1*8)=158
158 % 10 = 8
So 33889-68-8 is a valid CAS Registry Number.
InChI:InChI=1/C37H40N2O6/c1-38-14-12-24-19-31(42-4)33-21-27(24)28(38)16-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)41-3)17-29-35-25(13-15-39(29)2)20-34(43-5)36(40)37(35)45-33/h6-11,18-21,28-29,40H,12-17H2,1-5H3
33889-68-8Relevant articles and documents
Design, synthesis and in vitro anticancer research of novel tetrandrine and fangchinoline derivatives
Gao, Xiu-zheng,Lv, Xu-tao,Zhang, Rui-rui,Luo, Yang,Wang, Mu-xuan,Chen, Jia-shu,Zhang, Yu-kai,Sun, Bin,Sun, Jin-yue,Liu, Yu-fa,Liu, Chao
, (2021/02/22)
Cancer treatment is one of the major public health issues in the world. Tetrandrine (Tet) and fangchinoline (d-Tet) are two bis-benzyl isoquinoline alkaloids extracted from Stephania tetrandra S. Moore, and their antitumor activities have been confirmed.
REGIOSELECTIVE O-DEMETHYLATION OF BISBENZYLISOQUINOLINE ALKALOIDS
Kunitomo, Jun-ichi,Oshikata, Megumi,Akasu, Michinori,Ishii, Hisashi
, p. 937 - 942 (2007/10/02)
The cleavage of methyl ethers of several bisbenzylisoquinoline alkaloids was studied and regioselective O-demethylation was observed.
