33901-30-3

Basic information

• Product Name: 5-amino-1,3,4-thiadiazol-2(3H)-one
• CAS NO: 33901-30-3
• Molecular Formula: C₂H₃N₃OS
• Molecular Weight: 117.1297
• Mol File: 33901-30-3.mol
• Article Data: 4

Chemical Properties

• Density: 2.17g/cm³
• Refractive Index: 1.946
• CAS DataBase Reference: 5-amino-1,3,4-thiadiazol-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 5-amino-1,3,4-thiadiazol-2(3H)-one(33901-30-3)
• EPA Substance Registry System: 5-amino-1,3,4-thiadiazol-2(3H)-one(33901-30-3)

Safety Data

• Hazardous Substances Data: 33901-30-3(Hazardous Substances Data)

Upstream product

• 99903-75-0 N-(5-oxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-acetamide 
• 2937-80-6 1-carbamoyl-2-(thiocarbamoyl)hydrazine 
• 10153-17-0 2-carbamothioyl-N-phenylhydrazine carboxamide 
• 16841-84-2 2-amino-5-methoxy-1,3,4-thiadiazole 
• 75-44-5 phosgene 
• 79-19-6 thiosemicarbazide 

Downstream Products

• 85073-03-6 3-methyl-5-amino-1,3,4-thiadiazolin-2-one 
• 211388-16-8 3-acetyl-5-amino-1,3,4-thiadiazolin-2-one 
• 33901-26-7 5-benzoylamino-3H-[1,3,4]thiadiazol-2-one 
• 99903-75-0 N-(5-oxo-4,5-dihydro-[1,3,4]thiadiazol-2-yl)-acetamide 
• 211388-15-7 3-ethyl-5-amino-1,3,4-thiadiazolin-2-one 

Relevant articles and documents

A solid phosgene and thiosemicarbazide reaction for the preparation of 2 - hydroxy - 5 - amino - 1, 3, 4 - thiadiazole method

The invention relates to the preparation of 2-hydroxy-5-amino-1,3,4-thiadiazole. The preparation method comprises the following steps: taking thiosemicarbazide as the substrate, then adding thiosemicarbazide into a dichloromethane solution containing solid phosgene and triethanolamine, then adding a saturated potassium hydroxide solution, mixing, stirring to carry out reactions, and extracting the reaction products by ethyl acetate to obtain the target product. The provided novel method prepares 2-hydroxy-5-amino-1,3,4-thiadiazole from solid phosgene and thiosemicarbazide, has the advantages of mild conditions, convenience, low cost, high yield, and convenient and efficient post treatment, and is suitable for industrial production. The prepared 2-hydroxy-5-amino-1,3,4-thiadiazole can be used to prepare 1,3,4-thiadiazole drugs.

Process for the preparation of 1,3,4-thiadiazolone derivatives

A process for preparing 1,3,4-thiadiazolone compounds of the formula STR1 comprising reacting a 2-alkoxy-1,3,4-thiadiazole of the formula STR2 with hydrogen chloride in non-aqueous organic solvent under non-aqueous conditions at a temperature of from 0° t