339016-18-1

Basic information

• Product Name: 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE
• Synonyms: 2-Amino-4-chloro-6-(4-morpholinyl)pyrimidine;Albb-008892;2-amino-4-chloro-6-morpholinopyrimidine;4-chloro-6-morpholin-4-ylpyrimidin-2-amine(SALTDATA: FREE);(4-chloro-6-morpholino-pyrimidin-2-yl)amine;4-chloro-6-morpholino-pyrimidin-2-amine;4-chloro-6-(4-morpholinyl)-2-pyrimidinamine
• CAS NO: 339016-18-1
• Molecular Formula: C₈H₁₁ClN₄O
• Molecular Weight: 214.66
• Mol File: 339016-18-1.mol
• Article Data: 9

Chemical Properties

• Melting Point: 212-214℃
• Boiling Point: 473.5°Cat760mmHg
• Flash Point: 240.2°C
• Appearance: /
• Density: 1.399g/cm³
• Vapor Pressure: 3.91E-09mmHg at 25°C
• Refractive Index: 1.612
• PKA: 4.55±0.10(Predicted)
• CAS DataBase Reference: 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE(339016-18-1)
• EPA Substance Registry System: 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE(339016-18-1)

Safety Data

• Hazardous Substances Data: 339016-18-1(Hazardous Substances Data)

Usage

General Description

4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE is a chemical compound with the molecular formula C9H12ClN5O. It is a pyrimidine derivative with a chloro group and a morpholin-4-yl substituent. 4-CHLORO-6-MORPHOLIN-4-YLPYRIMIDIN-2-AMINE is commonly used in pharmaceutical research and drug development due to its potential as a medication for treatment of various diseases. Its unique structure and properties make it a valuable building block for the synthesis of novel pharmaceutical compounds. Additionally, it has shown promising biological activities, making it an important target for further investigation in the field of medicinal chemistry.

InChI:InChI=1/C8H11ClN4O/c9-6-5-7(12-8(10)11-6)13-1-3-14-4-2-13/h5H,1-4H2,(H2,10,11,12)

Upstream product

• 110-91-8 morpholine 
• 56-05-3 2-Amino-4,6-dichloropyrimidine 

Downstream Products

• 343373-72-8 4-(6-chloro-2-phenyl-pyrimidin-4-yl)-morpholine 
• 1072269-82-9 (4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-phenethyl-amine 
• 1072270-14-4 (4-chloro-6-morpholin-4-yl-pyrimidin-2-ylmethyl)-triphenyl-phosphonium bromide 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

Investigation of novel pesticides with insecticidal and antifungal activities: Design, synthesis and SAR studies of benzoylpyrimidinylurea derivatives

In order to find pesticides with insecticidal and antifungal activities, a series of novel benzoyl pyrimidinylurea derivatives were designed and synthesized. All target compounds were identified by 1H-NMR spectroscopy and HRMS. Insecticidal and antifungal activity of these compounds were evaluated and the structure-activity relationships (SAR) were clearly and comprehensively illustrated. Compound 7, with low toxicity to zebrafish (LC50 = 378.387 μg mL?1) showed 100% inhibition against mosquito (Culex pipiens pallens) at 0.25 μg mL?1. Both compounds 19 and 25 exhibited broad-spectrum fungicidal activity (>50% inhibitory activities against 13 phytopathogenic fungi), which were better than those of the commercial pesticide pyrimethanil (>50% inhibitory activities against eight phytopathogenic fungi). Furthermore, compounds 19 and 25 exhibited protective activity against Sclerotinia sclerotiorum on leaves of Brassica oleracea L. during in vivo experiments.

COMPOUNDS

Disclosed are novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, compositions containing them and their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis(ALS).