339046-14-9

Basic information

• Product Name: (5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid sodium salt
• CAS NO: 339046-14-9
• Molecular Weight: 342.454
• Mol File: 339046-14-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid sodium salt(CAS DataBase Reference)
• NIST Chemistry Reference: (5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid sodium salt(339046-14-9)
• EPA Substance Registry System: (5Z,8Z,11Z,13E,15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid sodium salt(339046-14-9)

Safety Data

• Hazardous Substances Data: 339046-14-9(Hazardous Substances Data)

Upstream product

• 54845-95-3 icomucret 
• 506-32-1 all cis 5,8,11,14-eicosatetraenoic acid 

Relevant articles and documents

Manufacture of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13-tetraenoic acid sodium salt for clinical trials

A robust synthesis of (5Z,8Z,11Z,13E)(15S)-15-hydroxyeicosa-5,8,11,13- tetraenoic acid (15(S)-HETE) sodium salt was established, utilising a biooxidation process. Treatment of arachidonic acid with soybean lipoxidase in 0.1 M sodium tetraborate buffer under oxygen pressure resulted in formation of the hydroperoxide, 15(S)-HPETE. Addition of sodium borohydride to the reaction mixture reduced the hydroperoxide to 15(S)-HETE, which was then purified by column chromatography. 15(S)-HETE sodium salt was prepared by treatment of an ethanol solution of HETE with aqueous sodium hydrogen carbonate. Multiple 10-g batches of 15(S)-HETE sodium salt with >98% enantiomeric excess and >98% chemical purity were prepared to support clinical trials.