33986-75-3

Basic information

• Product Name: 6-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-
• Synonyms: 6-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-;1,4-dihydro-4-oxoquinazoline-6-carboxylic acid;3,4-Dihydro-4-oxo-6-quinazolinecarboxylic acid;4-oxo-1,4-dihydroquinazoline-6-carboxylic acid;4(3H)-Oxoquinazoline-6-carboxylic acid, 97%
• CAS NO: 33986-75-3
• Molecular Formula: C9H6N2O3
• Molecular Weight: 190.15554
• Product Categories: CHIRAL CHEMICALS
• Mol File: 33986-75-3.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 477.226 °C at 760 mmHg
• Flash Point: 242.418 °C
• Appearance: /
• Density: 1.562 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.711
• Storage Temp.: 2-8°C
• PKA: 4.00±0.20(Predicted)
• CAS DataBase Reference: 6-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-(33986-75-3)
• EPA Substance Registry System: 6-Quinazolinecarboxylic acid, 3,4-dihydro-4-oxo-(33986-75-3)

Safety Data

• Safety Statements: 24/25
• Hazardous Substances Data: 33986-75-3(Hazardous Substances Data)

Usage

Chemical Properties

Off-white powder

InChI:InChI=1/C9H6N2O3/c12-8-6-3-5(9(13)14)1-2-7(6)10-4-11-8/h1-4H,(H,13,14)(H,10,11,12)

Upstream product

• 77287-34-4 formamide 
• 33890-03-8 4-aminoisophthalic acid 
• 67-64-1 acetone 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 152536-21-5 4-oxo-3,4-dihydro-quinazoline-6-carboxylic acid methyl ester 
• 1372890-01-1 methyl 4-oxo-3-[3-(trifluoromethyl)benzyl]-3,4-dihydroquinazoline-6-carboxylate 

Relevant articles and documents

A microwave catalysis in the aqueous phase a method of preparing Quinazolinone compounds

The invention discloses a method for preparing quinazolinone in water phase through microwave catalysis. The method comprises the step: by utilizing a water-soluble coordination compound (such as 8-hydroxyquinoline) as a catalyst, carrying out high-efficiency microwave catalysis on the reaction of 2-halogenated benzaldehyde and amidine salts in pure water phase. The invention relates to a method for preparing a quinazolinone compound, which is environment-friendly, simple and convenient to operate, safe and low-cost, and high-efficiency. Compared with the prior art, the method not only can be applicable to a great deal of functional groups, high in yield, fewer in side products, but also is simple and safe to operate, low in cost, and environment-friendly.

QUINAZOLINONE DERIVATIVES AND THEIR USE AS B-RAF INHIBITORS

The invention relates to chemical compounds of the formula (I): or pharmaceutically acceptable salts thereof, which possess B Raf inhibitory activity and are accordingly useful for their anti cancer activity and thus in methods of treatment of the human or animal body. The invention also relates to processes for the manufacture of said chemical compounds, to pharmaceutical compositions containing them and to their use in the manufacture of medicaments of use in the production of an anti-cancer effect in a warm blooded animal such as man.

PROCESS FOR PRODUCING QUINAZOLIN-4-ONE DERIVATIVE

A process for producing a quinazolin-4-one compound having the formula: [wherein R1, R2, R3 and R4 each represents a group not participating in the below-mentioned reaction, and R1, R2, R3 and R4 can be combined together to form a ring] which comprises reacting an anthranilic acid derivative having the formula: [wherein R5 is a hydrogen atom or a hydrocarbyl group] with a formic acid derivative in the presence of an ammonium carboxylate.