33994-12-6

Basic information

• Product Name: 3-bromo-1-(4-chlorophenyl)propan-1-one
• CAS NO: 33994-12-6
• Molecular Formula: C₉H₈BrClO
• Molecular Weight: 247.5162
• Mol File: 33994-12-6.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 328.7°C at 760 mmHg
• Flash Point: 152.6°C
• Density: 1.522g/cm³
• Vapor Pressure: 0.000186mmHg at 25°C
• Refractive Index: 1.572
• CAS DataBase Reference: 3-bromo-1-(4-chlorophenyl)propan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-bromo-1-(4-chlorophenyl)propan-1-one(33994-12-6)
• EPA Substance Registry System: 3-bromo-1-(4-chlorophenyl)propan-1-one(33994-12-6)

Safety Data

• Hazardous Substances Data: 33994-12-6(Hazardous Substances Data)

Usage

General Description

3-bromo-1-(4-chlorophenyl)propan-1-one is a chemical compound with the molecular formula C9H8BrClO. It is a yellow solid that is used in the synthesis of pharmaceuticals and other organic compounds. 3-bromo-1-(4-chlorophenyl)propan-1-one is a ketone, which means it contains a carbonyl group bonded to two alkyl or aryl groups. Its structure includes a bromine atom, a chlorine atom, and a phenyl group, making it useful in various chemical reactions and organic synthesis. It is important to handle this chemical with care, as it can be hazardous if not properly managed.

Upstream product

• 15486-96-1 3-Bromopropionyl chloride 
• 108-90-7 chlorobenzene 
• 7623-16-7 3-bromopropionyl bromide 
• 877-37-2 2-bromo-1-(4-chlorophenyl)-1-propanone 
• 6285-05-8 4'-chloropropiophenone 

Downstream Products

• 33994-16-0 3-Brom-p-chlorphenyl-propanol-1 
• 32594-52-8 β-(piperidino)-p-chloropropiophenone 
• 7448-87-5 p-chlorophenyl vinyl ketone 
• 108664-82-0 1-[3-(4-Chloro-phenyl)-3-oxo-propyl]-1H-quinolin-2-one 
• 108664-48-8 1-[2-(4-Chloro-benzoyl)-allyl]-1H-quinolin-2-one 
• 33994-20-6 3-Brom-1-chlor-1-p-chlorphenyl-propan 
• 1323153-64-5 1-(4-chlorophenyl)-4-(quinolin-2-yl) butan-1-one 
• 1323154-15-9 2-(3-(2-(4-chlorophenyl)-1,3-dioxolan-2-yl)propyl)quinoline 
• 1323154-29-5 C₁₁H₁₂BrClO₂ 
• 1453811-04-5 dimethyl 2-(4-chlorobenzoyl)cyclopropane-1,1-dicarboxylate 
• 1453810-92-8 C₁₄H₁₅ClO₅ 
• 73387-53-8 3-(4'-chlorophenyl)-1-methylpyrazole 
• 13941-59-8 3-(4-chlorophenyl)-2-isoxazoline 

Relevant articles and documents

Transformation of arenes into 3-arylpyrazoles and 3-arylisoxazolines with β-bromopropionyl chloride, hydrazine, and hydroxylamine

Successive treatment of arenes with β-bromopropionyl chloride and AlCl3, followed by the reactions with hydrazines and Na2CO3, and then with MnO2 gave the corresponding 3-arylpyrazoles in one pot in good to moderate yields. The same successive treatment of arenes with β-bromopropionyl chloride and AlCl3, followed by the reactions with hydroxylamine and KF gave the corresponding 3-arylisoxazolines in one pot in good to moderate yields.

PROCESS FOR THE PREPARATION OF ORGANIC BROMIDES

The present invention provides a process for the preparation of organic bromides, by a radical bromodecarboxylation of carboxylic acids with a bromoisocyanurate.

Enantioselective synthesis of quinolizidines and indolizidines via a catalytic asymmetric hydrogenation cascade

A catalytic enantioselective synthesis of a new class of quinolizidines and indolizidines is presented. An asymmetric Bronsted acid catalyzed hydrogenation cascade as well as a sequential Bronsted acid/metal catalyzed hydrogenation protocol of 2-substituted quinolines yields benzofused quinolizidines and indolizidines in good yields with high diastereo- and enantioselectivities. Georg Thieme Verlag Stuttgart - New York.