340-05-6

Basic information

• Product Name: 1-PHENYL-2,2,2-TRIFLUOROETHANOL
• Synonyms: (±)α-(trifluoromethyl)benzylalcohol;(R,S)-2,2,2-Trifluoro-1-phenyl-ethanol;1-Phenyl-2,2,2-trifluorethanol;Benzenemethanol,α-(trifluoromethyl)-,(±)-;α-(Trifluoromethyl)benzylalcohol;(+/-)-ALPHA-(TRIFLUOROMETHYL)BENZYLALCOHOL;ALPHA-(TRIFLUOROMETHYL)BENZYL ALCOHOL;2,2,2-TRIFLUORO-1-PHENYLETHANOL
• CAS NO: 340-05-6
• Molecular Formula: C₈H₇F₃O
• Molecular Weight: 176.14
• EINECS: 206-429-1
• Product Categories: Benzene series
• Mol File: 340-05-6.mol
• Article Data: 212

Chemical Properties

• Melting Point: 74.3-75.2 °C
• Boiling Point: 64-65 °C5 mm Hg(lit.)
• Flash Point: 184 °F
• Appearance: /liquid
• Density: 1.297 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.462
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 11.91±0.10(Predicted)
• BRN: 3197623
• CAS DataBase Reference: 1-PHENYL-2,2,2-TRIFLUOROETHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-2,2,2-TRIFLUOROETHANOL(340-05-6)
• EPA Substance Registry System: 1-PHENYL-2,2,2-TRIFLUOROETHANOL(340-05-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• F: 10-23
• HazardClass: IRRITANT
• Hazardous Substances Data: 340-05-6(Hazardous Substances Data)

Usage

Chemical Properties

Colorless liquid

InChI:InChI=1/C8H7F3O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5,7,12H

Upstream product

• 434-45-7 2,2,2-Trifluoroacetophenone 
• 17750-24-2 1-propyl-1,4-dihydronicotinamide 
• 952-92-1 1-Benzyl-1,4-dihydronicotinamide 
• 287-92-3 Cyclopentane 
• 79048-93-4 5-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 91999-49-4 6-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 91999-48-3 2-Methyl-1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 13502-54-0 1-(2',6'-Dichlorobenzyl)-1,4-dihydronicotinamide 
• 124898-12-0 trimethyl[(2,2,2-trifluoro-1-phenylethoxy)]silane 
• 75-46-7 trifluoromethan 
• 99838-02-5 tetraoctylammonium (2-pyrrolidonide) 
• 100-52-7 benzaldehyde 
• 75-63-8 Bromotrifluoromethane 
• 2314-97-8 iodotrifluoromethane 

Downstream Products

• 573-78-4 phthalic acid mono-(2,2,2-trifluoro-1-phenyl-ethyl ester) 
• 384-65-6 1-chloro-2,2,2-trifluoroethylbenzene 
• 434-42-4 1,1,1-trifluoro-2-bromo-2-phenylethane 
• 17659-27-7 1-benzoyloxy-1-phenyl-2,2,2-trifluoroethane 
• 125888-88-2 Phosphorochloridic acid 2,2,2-trifluoro-ethyl ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 100664-05-9 bis(2,2,2-trifluoroethyl) (α-trifluoromethylbenzyl) phosphate 
• 84877-46-3 2,2,2-trifluoro-1-phenylethyl trifluoromethanesulfonate 
• 93524-65-3 2-(2',5'-difluorophenyl)-1,1,1-trifluoro-2-phenylethane 
• 125888-91-7 Phosphorochloridic acid 2,2,3,3,4,4,5,5,5-nonafluoro-pentyl ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 100664-09-3 Phosphoric acid bis-(2,2,3,3,4,4,4-heptafluoro-butyl) ester 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 40121-55-9 1-phenyl-2,2,2-trifluoroethyl α-methoxy-α-(trifluoromethyl)phenylacetate 
• 128816-79-5 (2,2,2-trifluoroethyl)(2,2,3,3,4,4,5,5,6,6,7,7-dodecafluoroheptyl)(α-trifluoromethylbenzyl) phosphate 
• 135311-72-7 (S)-Cyano-fluoro-phenyl-acetic acid 2,2,2-trifluoro-1-phenyl-ethyl ester 
• 135311-72-7 1-phenyl-2,2,2-trifluoroethyl α-cyano-α-fluorophenylacetate 

Relevant articles and documents

Synthesis, Reactivity and Structural Properties of Trifluoromethylphosphoranides

Phosphoranides are interesting hypervalent species which serve as model compounds for intermediates or transition states in nucleophilic substitution reactions at trivalent phosphorus substrates. Herein, the syntheses and properties of stable trifluoromet

Homoleptic cobalt(II) phenoxyimine complexes for hydrosilylation of aldehydes and ketones without base activation of cobalt(II)

Air-stable, easy to prepare, homoleptic cobalt(II) complexes bearing pendant-modified phenoxyimine ligands were synthesized and determined. The complexes exhibited high catalytic performance for reducing aldehydes and ketones via catalytic hydrosilylation, where a hydrosilane and a catalytic amount of the cobalt(II) complex were added under base-free conditions. The reaction proceeded even in the presence of excess water, and excellent functional-group tolerance was observed. Subsequent hydrolysis gave the alcohol in high yields. Moreover, H2O had a critical role in activation of the Co(II) catalyst with hydrosilane. Several additional results also indicated that the cobalt(II) center acts as an active catalyst in the hydrosilylation of aldehydes and ketones.

Synthesis of Unsymmetric Triarylmethanes Bearing CF 3-Substituted All-Carbon Quaternary Stereocenters: 1,6-Arylation of δ-Trifluo romethyl Substituted para -Quinone Methides

Pre-synthesized δ-CF 3-δ-aryl-disubstituted para -quinone methides bearing δ-substituents were identified as isolable and storable substrates for 1,6-arylation reactions. A broad range of electron-rich arenes and heteroarenes participated in the arylation process, furnishing a wide array of unsymmetrical CF 3-substituted triarylmethanes in high efficiency. The mild and expeditious protocol exhibited broad scopes of both arene and para -quinone methide components.