3400-31-5

Basic information

• Product Name: NSC406902
• Synonyms: NSC406902;2-Chloro-N-MethylbenzaMide, 97%
• CAS NO: 3400-31-5
• Molecular Formula: C₈H₈ClNO
• Molecular Weight: 169.60822
• Mol File: 3400-31-5.mol
• Article Data: 13

Chemical Properties

• Melting Point: 119-121 °C
• Boiling Point: 297.3°Cat760mmHg
• Flash Point: 133.6°C
• Appearance: /
• Density: 1.196g/cm³
• Vapor Pressure: 0.00136mmHg at 25°C
• Refractive Index: 1.544
• PKA: 14.32±0.46(Predicted)
• CAS DataBase Reference: NSC406902(CAS DataBase Reference)
• NIST Chemistry Reference: NSC406902(3400-31-5)
• EPA Substance Registry System: NSC406902(3400-31-5)

Safety Data

• Hazardous Substances Data: 3400-31-5(Hazardous Substances Data)

Usage

General Description

NSC406902, also known as 5-Chloro-6-(3-methyl-1H-1,2,4-triazol-1-yl)pyridin-3-amine, is a chemical compound that belongs to the class of triazolopyridine derivatives. It is a member of the 1,2,4-triazole family, which is known for its diverse biological activities. NSC406902 has been studied for its potential therapeutic properties, particularly in the treatment of cancer and infectious diseases. It has shown promising anticancer activity in preclinical studies, with the ability to inhibit the growth of tumor cells. Additionally, it has demonstrated antimicrobial activity against certain pathogens. Further research is ongoing to explore the potential applications of NSC406902 in pharmaceutical and medical fields.

InChI:InChI=1/C8H8ClNO/c1-10-8(11)6-4-2-3-5-7(6)9/h2-5H,1H3,(H,10,11)

Upstream product

• 609-65-4 o-chlorobenzoyl chloride 
• 74-89-5 methylamine 
• 609-66-5 2-chlorobenzamide 
• 74-88-4 methyl iodide 
• 6154-14-9 N-chloromethylamine 
• 89-98-5 2-chloro-benzaldehyde 
• 7147-44-6 1-(2-chlorophenyl)ethanone oxime 
• 28123-61-7 N-Benzyl-N-methyl-o-chlorbenzamid 
• 118-91-2 ortho-chlorobenzoic acid 
• 610-96-8 methyl chlorobenzoate 
• 30004-67-2 N,S-dimethyl-S-phenylsulfoximine 
• 593-51-1 methylamine hydrochloride 
• 88070-48-8 N-methylbenzamide 
• 109-09-1 2-chloropyridine 

Downstream Products

• 77455-52-8 5-(2-chlorophenyl)-1-methyl-1H-tetrazole 
• 66896-90-0 N-methyl-N-(2-chlorobenzoyl)benzenesulfonamide 
• 66896-91-1 N-(2-Chloro-benzoyl)-4-methoxy-N-methyl-benzenesulfonamide 
• 127787-40-0 2-Chloro-N-methyl-N-trimethylsilanylmethyl-benzamide 
• 73280-30-5 N-methyl-o-chlorothiobenzamide 
• 225516-08-5 3-(3-bromo-4,5-dimethoxyphenyl)-7-chlorophthalide 
• 135186-78-6 pyriftalid 
• 1026189-70-7 3-(3-bromo-4,5-dimethoxy-phenyl)-7-chloro-1,3-dihydro-isobenzofuran-1-ol 
• 225517-59-9 1-(3-bromo-4,5-dimethoxyphenyl)-5-chloro-2,3-bis(methoxycarbonyl)-1,4-epoxy-1,2,3,4-tetrahydronaphthalene 
• 225517-22-6 1-(3-bromo-4,5-dimethoxyphenyl)-5-chloro-2-(methoxycarbonyl)naphthalene-3-carboxylic acid 
• 225517-53-3 1-(3-bromo-4,5-dimethoxyphenyl)-5-chloro-2,3-bis(methoxycarbonyl)naphthalene 
• 200411-13-8 3-Benzenesulfonyl-2-methyl-2,3-dihydro-isoindol-1-one 
• 200411-11-6 N-(2-chlorobenzoyl)-N-methylaminomethyl phenyl sulfone 
• 127818-28-4 2-Chloro-6-formyl-N-methyl-N-trimethylsilanylmethyl-benzamide 

Relevant articles and documents

The Pd-catalyzed synthesis of difluoroethyl and difluorovinyl compounds with a chlorodifluoroethyl iodonium salt (CDFI)

Herein, we report a simple and efficient method for the direct installation of chlorodifluoroethyl group onto aromatic molecules of various aromatic amides with a new 2-chloro,2,2-difluoroethyl(mesityl)iodonium salt (CDFI). Moreover, the chlorodifluoroeth

Formation of Aryl [1-Cyano-4-(dialkylamino)butadienyl] Ketones from Pyridines

Treatment of 2-chloropyridine with LDA and the Weinreb amide of benzoic acid afforded three unusual products, namely N -methylbenzamide, 2-chloropyridine-3-methanol, and the ring-opened addition product. This same final product could also be obtained from 2-chloro-3-benzoylpyridine on treatment with LDA. Mechanistic insight for the formation of these products is provided.

Palladium-Catalyzed Direct C-H Trifluoroethylation of Aromatic Amides

A simple and direct C-H trifluoroethylation of aromatic amides has been developed. The protocol is applicable to a variety of aromatic amides, including ones derived from amino acids. The developed method can be used for further modifications of peptides. Preliminary mechanistic studies have been done by isolating the reaction intermediate.