340165-34-6

Basic information

• Product Name: Benzenemethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-a-methyl-
• CAS NO: 340165-34-6
• Molecular Formula: C14H24O2Si
• Molecular Weight: 252.429
• Mol File: 340165-34-6.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: Benzenemethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-a-methyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-a-methyl-(340165-34-6)
• EPA Substance Registry System: Benzenemethanol, 4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-a-methyl-(340165-34-6)

Safety Data

• Hazardous Substances Data: 340165-34-6(Hazardous Substances Data)

Upstream product

• 149683-53-4 4-(tert-butyldimethylsilyloxy)acetophenone 
• 84494-81-5 1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-4-ethenyl benzene 
• 18162-48-6 tert-butyldimethylsilyl chloride 
• 99-93-4 4-Hydroxyacetophenone 

Downstream Products

• 1118710-97-6 tert-butyl[4-(1-methoxyethyl)phenoxy]dimethylsilane 
• 123-07-9 4-Ethylphenol 
• 93453-79-3 1-(4-hydroxyphenyl)ethanol 
• 1069111-70-1 2-(4-(tert-butyldimethylsilyloxy)phenyl)propanenitrile 
• 149683-53-4 4-(tert-butyldimethylsilyloxy)acetophenone 

Relevant articles and documents

Secondary Benzylation Using Benzyl Alcohols Catalyzed by Lanthanoid, Scandium, and Hafnium Triflate

The combination of a secondary benzyl alcohol and a metal triflate (e.g., La, Yb, Sc, and Hf triflate) in nitromethane was a highly effective secondary-benzylation system. Secondary benzylation of carbon (aromatic compounds, olefins, an enol acetate), nitrogen (amide derivatives), and oxygen (alcohols) nucleophiles was carried out with a secondary benzyl alcohol and 0.01-1 mol % of a metal triflate in the presence of water. Secondary benzyl alcohols and nucleophiles bearing acid-sensitive functional groups (e.g., tert-butyldimethylsilyloxy and acetoxy groups and methyl and benzyl esters) could be used for alkylation. Hf(OTf)4 was the most active catalyst for this alkylation, and trifluoromethanesulfonic acid (triflic acid, TfOH) was also a good catalyst. The catalytic activity of metal triflates and TfOH increased in the order La(OTf)3 3 3 4. A mechanistic study was also performed. The reaction of 1-phenylethanol (4a) in the presence of Sc(OTf) 3 in nitromethane gave an equilibrium mixture of 4a and bis(1-phenylethyl) ether (54). Addition of a carbon nucleophile to the equilibrium mixture gave alkylated product in high yield.

BRM TARGETING COMPOUNDS AND ASSOCIATED METHODS OF USE

The present disclosure relates to bifunctional compounds, which find utility as modulators of SMARCA2 or BRM (target protein). In particular, the present disclosure is directed to bifunctional compounds, which contain on one end a ligand that binds to the Von Hippel-Lindau E3 ubiquitin ligase, and on the other end a moiety which binds the target protein, such that the target protein is placed in proximity to the ubiquitin ligase to effect degradation (and inhibition) of target protein. The present disclosure exhibits a broad range of pharmacological activities associated with degradation/inhibition of target protein. Diseases or disorders that result from aggregation or accumulation of the target protein are treated or prevented with compounds and compositions of the present disclosure.

A Novel, Efficient, and Selective Cleavage of Alkyl tert-Butyldimethylsilyl Ethers Using the BiCl3/NaI System

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