34045-29-9

Basic information

• Product Name: 3-Aminopyrazole Hydrochloride Discontinued See: A628950
• Synonyms: 3-Aminopyrazole Hydrochloride Discontinued See: A628950;3-Aminopyrazole HydrochlorideDiscontinued
• CAS NO: 34045-29-9
• Molecular Formula: C3H6ClN3
• Product Categories: Bases & Related Reagents;Nucleotides
• Mol File: 34045-29-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 32-34°C
• Appearance: /
• CAS DataBase Reference: 3-Aminopyrazole Hydrochloride Discontinued See: A628950(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Aminopyrazole Hydrochloride Discontinued See: A628950(34045-29-9)
• EPA Substance Registry System: 3-Aminopyrazole Hydrochloride Discontinued See: A628950(34045-29-9)

Safety Data

• Hazardous Substances Data: 34045-29-9(Hazardous Substances Data)

Usage

Description

3-Aminopyrazole Hydrochloride, also known as A628950, is a chemical compound that has been discontinued. It is a yellow oil and was primarily used in the preparation of heterocyclic compounds of pharmaceutical interest. Its specific applications and properties are not widely documented due to its discontinuation.

Uses

Used in Pharmaceutical Industry:
3-Aminopyrazole Hydrochloride is used as a precursor in the synthesis of heterocyclic compounds for pharmaceutical applications. These compounds are of interest due to their potential therapeutic properties and may be used in the development of new drugs.
Please note that since 3-Aminopyrazole Hydrochloride has been discontinued, its current applications and relevance in the industry may be limited. The information provided is based on the materials given and may not cover all possible uses or properties of the compound.

Upstream product

• 1225387-53-0 3⁽⁵⁾-aminopyrazole 

Downstream Products

• 934758-92-6 5-chloro-1H-pyrazole 

Relevant articles and documents

Discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1 H -indol-2-yl)-2- (trifluoromethyl)-4,7-dihydropyrazolo[1,5- a ]pyrimidin-6-yl)((S)-2-(3- methylisoxazol-5-yl)pyrrolidin-1-yl)methanone as a potent and selective I Kur inhibitor

Previously disclosed dihydropyrazolopyrimidines are potent and selective blockers of IKur current. A potential liability with this chemotype is the formation of a reactive metabolite which demonstrated covalent binding to protein in vitro. When substituted at the 2 or 3 position, this template yielded potent IKur inhibitors, with selectivity over hERG which did not form reactive metabolites. Subsequent optimization for potency and PK properties lead to the discovery of ((S)-5-(methoxymethyl)-7-(1-methyl-1H-indol- 2-yl)-2-(trifluoromethyl)-4,7-dihydropyrazolo[1,5-a]pyrimidin-6-yl)((S) -2-(3-methylisoxazol-5-yl)pyrrolidin-1-yl)methanone (13j), with an acceptable PK profile in preclinical species and potent efficacy in the preclinical rabbit atrial effective refractory period (AERP) model.