34070-68-3

Basic information

• Product Name: 3-METHYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE
• Synonyms: 3-METHYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE;3-METHYL-3,4-DIHYDRO-1H-QUINOXALIN-2-ONE;3-METHYL-3,4-DIHYDRO-2(1H...;3-methyl-1,2,3,4-tetrahydroquinoxalin-2-one;3-methyl-3,4-dihydroquinoxalin-2(1H)-one;3,4-dihydro-3-methyl-2(1H)-Quinoxalinone
• CAS NO: 34070-68-3
• Molecular Formula: C₉H₁₀N₂O
• Molecular Weight: 162.19
• Mol File: 34070-68-3.mol
• Article Data: 2

Chemical Properties

• Melting Point: 138-141°C
• Boiling Point: 360.4°C at 760 mmHg
• Flash Point: 170.3°C
• Appearance: /
• Density: 1.119g/cm³
• Vapor Pressure: 2.23E-05mmHg at 25°C
• Refractive Index: 1.538
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly, Heated)
• CAS DataBase Reference: 3-METHYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE(34070-68-3)
• EPA Substance Registry System: 3-METHYL-3,4-DIHYDRO-2(1H)-QUINOXALINONE(34070-68-3)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 34070-68-3(Hazardous Substances Data)

Usage

Uses

3-Methyl-3,4-dihydro-1H-quinoxalin-2-one can be used as novel anti-cancer agents.

InChI:InChI=1/C9H10N2O/c1-6-9(12)11-8-5-3-2-4-7(8)10-6/h2-6,10H,1H3,(H,11,12)/t6-/m1/s1

Upstream product

• 215191-49-4 2-phenyl-1’H,5H-spiro[oxazole-4,2’-quinoxalin]-3’(4’H)-one 
• 600-22-6 pyruvic acid methyl ester 
• 95-54-5 1,2-diamino-benzene 

Downstream Products

• 317822-12-1 4-benzoyl-3-methyl-3,4-dihydroquinoxalin-2(1H)-one 
• 6640-55-7 2-methyl-1,2,3,4-tetrahydroquinoxaline 

Relevant articles and documents

Metal-free tandem cyclization/hydrosilylation to construct tetrahydroquinoxalines

A one-pot tandem procedure involving cyclization and sequential hydrosilylation of imines and amides under the catalysis of B(C6F5)3 has been developed for the step-economical construction of 1,2,3,4-tetrahydroquinoxalines directly from readily available 1,2-diaminobenzenes, α-ketoesters and low-cost, safe polymethylhydrosiloxane (PMHS). This metal-free approach provides various products in good to excellent yields, and displays a wide range of substrate scope and a high degree of functional group tolerance even to reduction-sensitive moieties. The choice of hydrosilanes is critical to the catalysis, and PMHS has proved to be optimal. Decreasing the amount of PMHS could enable the reaction to stop at the 3,4-dihydroquinoxalin-2(1H)-one stage. The procedure is convenient and scalable, and neither a dried solvent nor an inert atmosphere is required. Moreover, the enantioselective construction of these products was explored, and promising results were achieved.