340740-03-6

Basic information

• Product Name: (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzoyl-prolin-methyl-ester
• Synonyms: (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzoyl-prolin-methyl-ester
• CAS NO: 340740-03-6
• Molecular Weight: 363.529
• Mol File: 340740-03-6.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzoyl-prolin-methyl-ester(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzoyl-prolin-methyl-ester(340740-03-6)
• EPA Substance Registry System: (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzoyl-prolin-methyl-ester(340740-03-6)

Safety Data

• Hazardous Substances Data: 340740-03-6(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 98-88-4 benzoyl chloride 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 31560-20-0 (2S,4R)-1-benzoyl-4-hydroxypyrrolidine-2-carboxylic acid methyl ester 
• 18162-48-6 tert-butyldimethylsilyl chloride 

Downstream Products

• 340740-21-8 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-2-methoxymethyl-1-trityl-pyrrolidin 
• 340740-11-6 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzyl-2-methoxy-methyl-pyrrolidin 
• 154343-02-9 (2S,4R)-4-{[1-(tert-butyl)-1,1-dimethylsilyl]-oxy}-1-benzyl-2-hydroxy-methyl-pyrrolidin 

Relevant articles and documents

Asymmetric synthesis of α-branched primary amines on solid support via novel hydrazine resins

Matrix presented Two novel chiral hydrazine resins for asymmetric solid-phase synthesis have been developed. The enantiopure β-methoxyamino auxiliaries, derived from frans-4-hydroxy-(S) -proline and (R) -leucine, were attached to Merrifield resin and transformed into their corresponding hydrazines. Immobilization of various aldehydes, followed by 1,2-addition of organolithium reagents to the resulting enantiopure hydrazones and reductive cleavage from the solid support, furnished α-branched amines, which were isolated as their corresponding amides in good overall yields and enantiomeric excesses of up to 86%.