341-69-5 Usage
Description
Orphenadrine Hydrochloride is an odorless white or almost white crystalline powder with a pH of approximately 5.5 in its aqueous solution. It has a bitter numbing taste and is defined as a hydrochloride consisting of equimolar amounts of orphenadrine and hydrogen chloride. Chemically, it is a white or almost white crystalline powder.
Uses
1. Used in Pharmaceutical Industry:
Orphenadrine Hydrochloride is used as a muscle relaxant for the treatment of muscle spasms and pain. It works by blocking nerve signals in the brain and helps to provide relief from muscle pain and discomfort.
2. Used in Neurological Applications:
Orphenadrine Hydrochloride is used as an antispasmodic agent for the management of involuntary muscle movements and tremors. It helps to reduce the frequency and severity of these movements, improving the quality of life for patients suffering from neurological disorders.
3. Used in Pain Management:
Orphenadrine Hydrochloride is used as an analgesic agent for the relief of mild to moderate pain. It is particularly effective in managing pain associated with muscle spasms and strains.
4. Used in Movement Disorders:
Orphenadrine Hydrochloride is used as an anticholinergic agent for the treatment of movement disorders such as Parkinson's disease and Huntington's disease. It helps to alleviate symptoms like tremors, rigidity, and bradykinesia by blocking the action of acetylcholine in the brain.
5. Used in Sleep Aids:
Orphenadrine Hydrochloride is used as a sedative-hypnotic agent for the treatment of insomnia and other sleep disorders. It helps to induce sleep and improve sleep quality by promoting relaxation and reducing muscle tension.
Air & Water Reactions
May be sensitive to prolonged exposure to light and air. Water soluble.
Reactivity Profile
ORPHENADRINE HYDROCHLORIDE is incompatible with strong oxidizers.
Fire Hazard
Flash point data for ORPHENADRINE HYDROCHLORIDE are not available; however, ORPHENADRINE HYDROCHLORIDE is probably combustible.
Biochem/physiol Actions
Muscarinic receptor antagonist; H1 histamine receptor antagonist; muscle relaxant. Orphenadrine has also been reported to inhibit the noradrenergic transporter and to block the NMDA receptor ion channel.
Clinical Use
Anti-muscarinic:
Parkinsonism
Drug induced extra-pyramidal symptoms
Safety Profile
Poison by ingestion, intravenous, intraperitoneal, and subcutaneous routes. Human systemic effects: mydriasis @updlaryd ilation), hallucinations, distorted perceptions, pulse rate increase, intracranial pressure increase. An experimental teratogen. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx and HCl
Drug interactions
Potentially hazardous interactions with other drugs
None known
Metabolism
Orphenadrine is almost completely metabolised to at least
8 metabolites in the liver.
It is mainly excreted in the urine as metabolites and small
amounts of unchanged drug
Check Digit Verification of cas no
The CAS Registry Mumber 341-69-5 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 3,4 and 1 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 341-69:
(5*3)+(4*4)+(3*1)+(2*6)+(1*9)=55
55 % 10 = 5
So 341-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C18H23NO/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16/h4-12,18H,13-14H2,1-3H3/p+1/t18-/m0/s1
