3413-15-8Relevant articles and documents
Visible Light-Promoted Magnesium, Iron, and Nickel Catalysis Enabling C(sp3)-H Lactonization of 2-Alkylbenzoic Acids
Li, Sasa,Su, Mincong,Sun, Jie,Hu, Kunjun,Jin, Jian
supporting information, p. 5842 - 5847 (2021/07/31)
A mild and practical C(sp3)-H lactonization protocol has been achieved by merging photocatalysis and magnesium (iron, nickel) catalysis. A diverse range of 2-alkylbenzoic acids with a variety of substitution patterns could be transformed into the corresponding phthalide products. Based on the mechanistic experimentation and reported prior studies, a possible mechanism for the benzylic oxidative lactonization reaction was proposed with the hypothetic photoactive ternary complex formed between the 2-alkylbenzoic acid substrate, magnesium ion, and bromate anion.
Novel purification method of butylphthalide
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Paragraph 0027-0038, (2021/06/26)
The invention aims to provide a simple and easy-to-operate method for preparing high-purity butylphthalide. The method comprises the following steps: subjecting o-formylbenzoic acid to reacting with a Grignard reagent to prepare a reaction solution of butylphthalide, regulating the reaction solution to a certain pH value by using a specific acid at a certain temperature, extracting a product by using an organic solvent, and washing an organic phase by using an alkali so as to obtain high-purity butylphthalide. According to the method, silica gel column chromatography or a high-temperature and high-vacuum distillation method is not used; tedious multiple acid and alkali adjusting procedures for purifying butylphthalide is avoided; operation is simple and effective; and the method is suitable for industrial large-scale production.
Method for synthesizing 3 - n -butyl - l (3H)-isobenzofuranone (by machine translation)
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Paragraph 0046-0049, (2020/07/24)
The invention discloses a method for synthesizing 3 - n -butyl - l (3H)-isobenzofuranone, firstly mixing Grignard reagent with Lewis acid, adjusting pH to acidity by an acid reagent, extracting with an organic solvent, concentrating and removing an organic solvent to obtain 3 - n -butyl - l (3H)-isobenzofuranone. (by machine translation)