34145-05-6

Basic information

• Product Name: 2,5-DICHLOROBENZYL ALCOHOL
• Synonyms: 2,5-DICHLOROBENZYL ALCOHOL;RARECHEM AL BD 0427;Benzenemethanol, 2,5-dichloro-;2,5-dichlorobenzylic alcohol;(2,5-Dichloro-phenyl)-methanol;2,5-Dichlorobenzylalcohol,99%;2,5-DICHLOROBENZYL ALCOHOL 99%;2,5-Dichlorobenzenemethanol
• CAS NO: 34145-05-6
• Molecular Formula: C₇H₆Cl₂O
• Molecular Weight: 177.03
• EINECS: 251-850-6
• Product Categories: Benzhydrols, Benzyl & Special Alcohols;Alcohols;C7 to C8;Oxygen Compounds
• Mol File: 34145-05-6.mol
• Article Data: 5

Chemical Properties

• Melting Point: 79-80 °C(lit.)
• Boiling Point: 266℃
• Flash Point: 114℃
• Appearance: white fine crystalline powder
• Density: 1.392
• Vapor Pressure: 0.00452mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• Storage Temp.: 2-8°C
• PKA: 13.69±0.10(Predicted)
• BRN: 3240770
• CAS DataBase Reference: 2,5-DICHLOROBENZYL ALCOHOL(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-DICHLOROBENZYL ALCOHOL(34145-05-6)
• EPA Substance Registry System: 2,5-DICHLOROBENZYL ALCOHOL(34145-05-6)

Safety Data

• Statements: 36/37/38
• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 34145-05-6(Hazardous Substances Data)

Usage

Description

2,5-Dichlorobenzyl alcohol is a white, fine crystalline powder that plays a significant role in the catalyzed oxidation of alcohols to aldehydes or ketones using H5IO6 as an oxidant and [Ru(acac)2(CH3CN)2]PF6 (acac = acetylacetone) as a catalyst. This chemical compound is known for its ability to facilitate important chemical reactions in the synthesis of various organic compounds.

Uses

Used in Chemical Synthesis:
2,5-Dichlorobenzyl alcohol is used as a reactant in the chemical synthesis of aldehydes and ketones. Its application is crucial for the production of a wide range of organic compounds, which can be utilized in various industries, including pharmaceuticals, agrochemicals, and the fragrance industry.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2,5-Dichlorobenzyl alcohol is used as an intermediate in the synthesis of various drugs and pharmaceutical compounds. Its ability to be oxidized to aldehydes or ketones makes it a valuable component in the development of new medications with potential therapeutic applications.
Used in Agrochemical Industry:
2,5-Dichlorobenzyl alcohol is also utilized in the agrochemical industry for the synthesis of active ingredients in pesticides and other agricultural chemicals. Its role in the production of these compounds contributes to the development of more effective and targeted pest control solutions.
Used in Fragrance Industry:
In the fragrance industry, 2,5-Dichlorobenzyl alcohol is employed as a starting material for the creation of various scent compounds. Its chemical properties make it suitable for the development of unique and complex fragrances used in perfumes, cosmetics, and other scented products.
Overall, 2,5-Dichlorobenzyl alcohol is a versatile chemical compound with a wide range of applications across different industries, primarily due to its role in the catalyzed oxidation of alcohols to aldehydes or ketones. Its chemical properties and reactivity make it an essential component in the synthesis of various organic compounds, contributing to the development of new products and technologies in the pharmaceutical, agrochemical, and fragrance industries.

InChI:InChI=1/C7H6Cl2O/c8-6-1-2-7(9)5(3-6)4-10/h1-3,10H,4H2

Upstream product

• 6361-23-5 2,5-dichloro-benzaldehyde 
• 2745-49-5 1,4-Dichloro-2-chloromethyl-benzene 
• 100-52-7 benzaldehyde 
• 2905-69-3 methyl 2,5-dichlorobenzoate 
• 50-79-3 2,5-dichlorobenzoic acid 

Downstream Products

• 5330-38-1 4-chloro-2-hydroxymethylphenol 
• 90273-71-5 Chlor-essigsaeure-(2,5-dichlor-benzylester) 
• 6361-23-5 2,5-dichloro-benzaldehyde 
• 2745-49-5 1,4-Dichloro-2-chloromethyl-benzene 
• 5398-79-8 2-(2,5-dichlorophenyl)acetic acid 
• 3218-50-6 2-(2,5-dichlorophenyl)acetonitrile 
• 73075-59-9 5,8-dichloroisoquinoline 
• 89315-57-1 5,8-Dichloro-1,2,3,4-tetrahydro-isoquinoline 
• 492-22-8 thio-xanthene-9-one 
• 83986-05-4 5-Chloro-2-(2-fluorophenylthio)benzaldehyde 

Relevant articles and documents

Controlled Reduction of Carboxamides to Alcohols or Amines by Zinc Hydrides

New protocols for controlled reduction of carboxamides to either alcohols or amines were established using a combination of sodium hydride (NaH) and zinc halides (ZnX2). Use of a different halide on ZnX2 dictates the selectivity, wherein the NaH-ZnI2 system delivers alcohols and NaH-ZnCl2 gives amines. Extensive mechanistic studies by experimental and theoretical approaches imply that polymeric zinc hydride (ZnH2)∞ is responsible for alcohol formation, whereas dimeric zinc chloride hydride (H?Zn?Cl)2 is the key species for the production of amines.

Hydrogenation of Esters to Alcohols Catalyzed by Defined Manganese Pincer Complexes

The first manganese-catalyzed hydrogenation of esters to alcohols has been developed. The combination of Mn(CO)5Br with [HN(CH2CH2P(Et)2)2] leads to a mixture of cationic and neutral Mn PNP pincer complexes, which enable the reduction of various ester substrates, including aromatic and aliphatic esters as well as diesters and lactones. Notably, related pincer complexes with isopropyl or cyclohexyl substituents showed very low activity.

Tricyclic psychotropic agents containing two chalcogen atoms in the central ring: 8-substituted 6-(4-piperidyl)-6H-dibenz[b,e]-1,4-oxathiepins

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