34161-81-4

Basic information

• Product Name: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid
• Synonyms: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid
• CAS NO: 34161-81-4
• Molecular Weight: 305.354
• Mol File: 34161-81-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid(34161-81-4)
• EPA Substance Registry System: 5-methyl-2-[(4-methylphenyl)sulfonamido]benzoic acid(34161-81-4)

Safety Data

• Hazardous Substances Data: 34161-81-4(Hazardous Substances Data)

Upstream product

• 941-55-9 4-toluenesulfonyl azide 
• 99-04-7 m-Toluic acid 
• 98-59-9 p-toluenesulfonyl chloride 
• 1426922-36-2 N-[2-(4'-methylbenzenesulfonamido)-5-methylbenzoyl]-S-methyl-S-phenylsulfoximine 
• 2941-78-8 2-Amino-5-methylbenzoic acid 

Downstream Products

• 599-86-0 4-methyl-N-(4-methylphenyl)benzenesulfonamide 
• 1315477-58-7 5-methyl-3-phenyl-1-tosyl-1H-indole-2-carbaldehyde 
• 1315477-41-8 1-(5-methyl-2-(tosylamino)phenyl)-1-phenylprop-2-yn-1-ol 
• 28561-54-8 2-Benzoyl-4-methyl-N-(p-toluolsulfonyl)-anilid 
• 132353-94-7 [[2-(1-Chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-(toluene-4-sulfonyl)-amino]-acetic acid methyl ester 
• 132354-04-2 methyl N-(2-methylthiocarbonylmethyl-4-methylphenyl)-N-(toluene-4-sulphonyl)-2-aminoacetate 
• 132353-95-8 N-Allyl-N-[2-(1-chloro-2,2-bis-methylsulfanyl-vinyl)-4-methyl-phenyl]-4-methyl-benzenesulfonamide 
• 132354-03-1 (E)-N-<2-(2-methylsulphinyl-2-methylthiovinyl)-4-methylphenyl>toluene-4-sulphonamide 
• 34161-85-8 N-(2-formyl-4-methylphenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Late-Stage Amination of Drug-Like Benzoic Acids: Access to Anilines and Drug Conjugates through Directed Iridium-Catalyzed C?H Activation

The functionalization of C?H bonds, ubiquitous in drugs and drug-like molecules, represents an important synthetic strategy with the potential to streamline the drug-discovery process. Late-stage aromatic C?N bond–forming reactions are highly desirable, but despite their significance, accessing aminated analogues through direct and selective amination of C?H bonds remains a challenging goal. The method presented herein enables the amination of a wide array of benzoic acids with high selectivity. The robustness of the system is manifested by the large number of functional groups tolerated, which allowed the amination of a diverse array of marketed drugs and drug-like molecules. Furthermore, the introduction of a synthetic handle enabled expeditious access to targeted drug-delivery conjugates, PROTACs, and probes for chemical biology. This rapid access to valuable analogues, combined with operational simplicity and applicability to high-throughput experimentation has the potential to aid and considerably accelerate drug discovery.

Method for Preparing Derivatives of Anthranilic acid and Anti-inflammatory Use Thereof

The present invention relates to a production method of anthranilic acid derivatives which reacts benzoic acid derivatives and phenylsulfonyl azide derivatives under the presence of a [IrCp*Cl_2]_2 catalyst; and relates to an anti-inflammatory use of the

Sulfoximine directed intermolecular o-C-H amidation of arenes with sulfonyl azides

The Ru(II)-catalyzed intermolecular o-C-H amidation of arenes in N-benzoylated sulfoximine with sulfonyl azides is demonstrated. The reaction proceeds with broad substrate scope and tolerates various functional groups. Base hydrolysis of the amidation product provides the anthranilic acid derivatives and methylphenyl sulfoximine (MPS) directing group. This method is successfully employed for the synthesis of HMR 1766.