34218-77-4

Basic information

• Product Name: O(4)-methyluridine
• Synonyms: O(4)-methyluridine;4-O-Methyl-Uridine
• CAS NO: 34218-77-4
• Molecular Formula: C₁₀H₁₄N₂O₆
• Molecular Weight: 258.229
• Mol File: 34218-77-4.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 485.9 °C at 760 mmHg
• Flash Point: 247.6 °C
• Appearance: /
• Density: 1.68 g/cm³
• Vapor Pressure: 1.77E-11mmHg at 25°C
• Refractive Index: 1.658
• CAS DataBase Reference: O(4)-methyluridine(CAS DataBase Reference)
• NIST Chemistry Reference: O(4)-methyluridine(34218-77-4)
• EPA Substance Registry System: O(4)-methyluridine(34218-77-4)

Safety Data

• Hazardous Substances Data: 34218-77-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H14N2O6/c1-17-6-2-3-12(10(16)11-6)9-8(15)7(14)5(4-13)18-9/h2-3,5,7-9,13-15H,4H2,1H3/t5-,7-,8-,9-/m1/s1

Upstream product

• 288-88-0 1,2,4-Triazole 
• 67-56-1 methanol 
• 1748-04-5 tribenzoyl uridine 
• 6674-22-2 1,8-diazabicyclo[5.4.0]undec-7-ene 

Downstream Products

• 67-56-1 methanol 
• 58-96-8 uridine 
• 65-46-3 CYTIDINE 
• 489-59-8 2-amino-1-(β-D-ribofuranosyl)pyrimidin-4(1H)-one 
• 173169-41-0 1-{(2R,3R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3,4-dihydroxy-tetrahydro-furan-2-yl}-4-methoxy-1H-pyrimidin-2-one 
• 211676-84-5 1-[(2R,3R,4R,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-3-(tert-butyl-dimethyl-silanyloxy)-4-hydroxy-tetrahydro-furan-2-yl]-4-methoxy-1H-pyrimidin-2-one 

Relevant articles and documents

24. Synthesis of (15N2)[17O]urea, (15N2)[O2,O4-17O 2]uridine, and (15N3)[O2-17O]cytidine

A general synthetic approach for the synthesis of 15N- and 17O-doubly labelled pyrimidine nucleosides is described. The 15N isotopes in uridine and the 17O isotope in the urea-derived carbonyl group of uridine and cytidine originate from (15N2)[17O]urea (5) which was synthesized from 15NH4Cl, thiophosgene (1), and H2[17O]. The third 15N isotope of cytidine in 4-position stems from the substitution of the 1,2,4-triazole moiety of (15N2)[O2-17O]uridine derivative 8a/b with 15NH4OH. Hydrolysis of the same key intermediate 8a/b with Na[17O]H/H2[17O] introduced the second 17O isotope into the 4-position of uridine. The 15N- and 17O-NMR spectra of the target compounds 12 and 14 in phosphate-buffered H2O serve as references for heteronuclear NMR spectra of labelled RNA fragments.