34240-68-1

Basic information

• Product Name: 2-hydroxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate
• Synonyms: ethanaminium, 2-[[hydroxy[2-hydroxy-3-(octadecyloxy)propoxy]phosphinyl]oxy]-N,N,N-trimethyl-, inner salt
• CAS NO: 34240-68-1
• Molecular Formula: C₂₆H₅₆NO₆P
• Molecular Weight: 509.6997
• Mol File: 34240-68-1.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate(34240-68-1)
• EPA Substance Registry System: 2-hydroxy-3-(octadecyloxy)propyl 2-(trimethylammonio)ethyl phosphate(34240-68-1)

Safety Data

• Hazardous Substances Data: 34240-68-1(Hazardous Substances Data)

Upstream product

• 74389-69-8 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine 
• 129170-96-3 C₂₉H₅₇N₂O₇P 
• 645-84-1 choline phosphate 
• 111860-28-7 (2S,3S)-2,3-Bis-benzoyloxy-3-carboxy-propionate((R)-2-hydroxy-3-octadecyloxy-propyl)-dimethyl-sulfonium; 
• 16245-97-9 octadecyl glycidyl ether 
• 80483-86-9 2-O-Benzyl-1-O-octadecyl-sn-glycero-3-phosphorylcholin 
• 108180-28-5 rac-2-myristoyl-1-octadecyl-3-phosphocholine 
• 871693-93-5 (R)-1-O-octadecyl-2-O-benzyl-3-(p-toluenesulfonyl)glycerol 
• 112-92-5 1-octadecanol 
• 55357-38-5 choline tosylate 
• 80707-93-3 (S)-1-O-octadecyl-2-O-benzyl-glycerol 
• 83526-55-0 (R)-1-O-octadecyl-3-(p-toluenesulfonyl)-glycerol 
• 10567-22-3 (R)-octadecylglycerol 
• 6129-13-1 batyl alcohol 

Downstream Products

• 74389-69-8 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine 
• 85733-91-1 1-O-octadecyl-2-acetyl-sn-glycero-3-phosphocholine 
• 80707-96-6 Ro 15-4454 

Relevant articles and documents

Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids

Two series of erlotinib-alkylphospholipid hybrids were prepared and evaluated for their antiproliferative activities against a panel of four cell lines representing lung, breast, liver and skin cancers using erlotinib and miltefosine as reference standards. Amide analogs elicited more enhanced cytotoxic activity than analogous esters. Amide derivatives 8d and 8e exhibited promising broad-spectrum antiproliferative activity and higher efficacy than reference erlotinib and miltefosine. Their cellular GI50 values was in the ranges of 24.7–46.9 μM and 26.8–43.1 μM for 8e and 8d respectively. Assay results of the inhibitory activity of the prepared compounds on EGFR kinase reaction and Akt phosphorylation in conjugation with statistical correlation analysis indicated that other mechanisms might contribute to their elicited cytotoxicities. In addition, statistical correlation analysis revealed that mechanisms of elicited cytotoxicities for amide series might be different from ester series. In addition, correlation analysis indicated variations in the mechanisms according to the types of cell line.

Synthesis and biological activity of anticancer ether lipids that are specifically released by phospholipase A2 in tumor tissue

The clinical use of anticancer lipids is severely limited by their ability to cause lysis of red blood cells prohibiting intravenous injection. Novel delivery systems are therefore required in order to develop anticancer ether lipids (AELs) into clinicall

Formation of a Structural Isomer of Platelet Activating Factor on the Acetylation of 1-Alkyl-sn-Glycero-3-Phosphocholines

The key stage in the synthesis of the platelet activating factor (PAT) - the acetylation of 1-alkyl-sn-glycero-3-phosphocholines (lyso-PAT) with acetic anhydride - has been studied.The formation of a structural isomer of PAT - 1-alkyl-3-acetyl-sn-glycero-3-phosphocholines - as a by-product when the reaction is carried out in the presence of bases (triethylamine, 4-dimethylaminopyridine) has been shown.Acetylation under the conditions of acid catalysis gave the isomerically pure PAT.The mechanism of the reaction leading to the formation of the PAT isomer is discussed.