34260-70-3Relevant articles and documents
SMALL MOLECULE MODULATORS OF IL-17
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Page/Page column 68, (2020/09/30)
The present invention relates to a compound according to formula I and pharmaceutically acceptable salts, hydrates, or solvates thereof. The invention further relates to, to said compounds for use in therapy, to pharmaceutical compositions comprising said
ANTICANCER AGENTS BASED ON AMINO ACID DERIVATIVES
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Page/Page column 36, (2011/02/24)
The present invention provides compounds of formula (I): in which T is L or -A-NH-C(O)-L-; L is -(CH2)n- or -(CH2)p-Z-; A is -(CH2)m- or an alkyl component of a naturally occurring amino acid; R is -CO2R1, -CH2OH, -C(O)NH(hydroxyphenyl) or C(S)NH(hydroxyphenyl); R1 is H or is C1-C12 alkyl; X is -OH, OSO2R2, -Cl, -Br, or -I; R2 is C1-C12 alkyl or -CF3; Z is phenyl or naphthyl; m is an integer having a value of 1 to 20; n is an integer having a value of 1 to 20; and p is an integer having a value of 1 to 20 or an enantiomer, diastereoisomer, racemic mixture, pharmaceutically acceptable salt, solvate or prodrug thereof. These compounds can be useful as anticancer agents.
Synthesis of two novel cyclic biphenyl ether analogs of an inhibitor of HCV NS3 protease
Marchetti, Antonella,Ontoria, Jesus M.,Matassa, Victor G.
, p. 1000 - 1002 (2007/10/03)
The synthesis of two cyclic ether analogs of a tetrapeptide inhibitor of the hepatitis C virus NS3 protease has been carried out using intramolecular nucleophilic aromatic substitution (S(N)Ar) reactions of ruthenium π-aryl complexes of pre-assembled trip