342777-09-7Relevant articles and documents
Structure-activity relationship on the human EP3 prostanoid receptor by use of solid-support chemistry
Juteau, Helene,Gareau, Yves,Labelle, Marc,Lamontagne, Sonia,Tremblay, Nathalie,Carriere, Marie-Claude,Sawyer, Nicole,Denis, Danielle,Metters, Kathleen M.
, p. 747 - 749 (2007/10/03)
Potent and selective EP3 receptor ligands were found by making a library using solid-support chemistry. These compounds can be obtained by a Suzuki coupling reaction of a solid-supported benzyl bromide using various boronic acids. The yields obtained for this reaction were in the range of 24-95% of arylmethyl cinnamic acid I after cleavage from the Wang resin,