342786-08-7

Basic information

• Product Name: 2-[3-(1,4-dioxo-3-phenyl-3,4-dihydro-2(1H)-phthalazinyl)propyl]-3-phenyl-2,3-dihydro-1,4-phthalazinedione
• Synonyms: 2-[3-(1,4-dioxo-3-phenyl-3,4-dihydro-2(1H)-phthalazinyl)propyl]-3-phenyl-2,3-dihydro-1,4-phthalazinedione
• CAS NO: 342786-08-7
• Molecular Formula: C31H24N4O4
• Molecular Weight: 516.54666
• Mol File: 342786-08-7.mol
• Article Data: 2

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-[3-(1,4-dioxo-3-phenyl-3,4-dihydro-2(1H)-phthalazinyl)propyl]-3-phenyl-2,3-dihydro-1,4-phthalazinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[3-(1,4-dioxo-3-phenyl-3,4-dihydro-2(1H)-phthalazinyl)propyl]-3-phenyl-2,3-dihydro-1,4-phthalazinedione(342786-08-7)
• EPA Substance Registry System: 2-[3-(1,4-dioxo-3-phenyl-3,4-dihydro-2(1H)-phthalazinyl)propyl]-3-phenyl-2,3-dihydro-1,4-phthalazinedione(342786-08-7)

Safety Data

• Hazardous Substances Data: 342786-08-7(Hazardous Substances Data)

Upstream product

• 4870-16-0 N-anilinophthalimide 
• 109-64-8 1,3-dibromo-propane 
• 5439-98-5 2-phenyl-2,3-dihydro-phthalazine-1,4-dione 
• 109-70-6 1.3-chlorobromopropane 

Relevant articles and documents

Synthesis and pharmacological evaluation of new arylpiperazines. 3-{4-[4-(3-chlorophenyl)-1-piperazinyl]butyl}-quinazolidin-4-one - A dual serotonin 5-HT1A/5-HT2A receptor ligand with an anxiolytic-like activity

On the basis of systematic studies on the structure-activity relationships in arylpiperazine group of serotonin ligands, 12 new derivatives containing quinazolidin-4(3H)-one (1-4), 2-phenyl-2,3-dihydrophthalazine-1,4-dione (5-8) or 1-phenyl-1,2-dihydropyridazine-3,6-dione (9-12) fragments were synthesized. The majority of the tested compounds (2, 4, 7, 8 and 10-12) showed a high affinity for 5-HT1A receptors (Ki=11-54 nM) and two (1, 2) were found active at 5-HT2A sites (16 and 68 nM, respectively). All the new 5-HT1A ligands tested in vivo revealed an antagonistic activity at postsynaptic 5-HT1A receptors, and three of them behaved as agonists at presynaptic ones. Additionally, both the meta-chlorophenylpiperazine derivatives containing quinazolidin-4-one fragment showed features of 5-HT2A receptor antagonists. The dual 5-HT1A/5-HT2A receptor ligand (2) was further tested for its potential psychotropic activity. It showed a distinct anxiolytic-like activity in a conflict drinking test in rats and the observed effect was more potent in terms of the active dose, than that produced by diazepam (used as a reference drug).